◀ Back to EPHB2
EPHB2 — FYN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN)
→
FAP1 (PTPN13)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Palmer et al., Mol Cell 2002
Evidence: assay
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Palmer et al., Mol Cell 2002
Evidence: assay
-
Reactome Reaction:
FYN
→
EPHB2
(reaction)
Marignani et al., J Cell Biol 2001, Palmer et al., Mol Cell 2002, Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Cell Biol 2003, Marston et al., Nat Cell Biol 2003, Zhang et al., J Neurosci 2005, Cowan et al., Neuron 2005, Tolias et al., Proc Natl Acad Sci U S A 2007
-
Reactome Reaction:
FYN
→
EPHB2
(direct_complex)
-
Reactome Reaction:
FYN
→
EPHB2
(indirect_complex)
Palmer et al., Mol Cell 2002
Text-mined interactions from Literome
Kawabe et al., Am J Physiol Heart Circ Physiol 2004
:
Taken together, caveolin in caveolae may keep
ERK inactive, but when caveolin is translocated to noncaveolar sites in response to stretch stress, caveolin mediates stretch
induced ERK activation through an association with
beta1-integrins/Fyn/Shc
Zhao et al., J Biol Chem 2005
(Cell Transformation, Neoplastic) :
Small interfering RNA
Fyn also
suppressed 2-AG induced
ERK phosphorylation
Godeny et al., Am J Physiol Cell Physiol 2006
:
In a concurrently submitted article, we show that ANG II-induced
ERK1/2 activation is
mediated by both
c-Src/Yes/Fyn and heterotrimeric G protein/PKCzeta dependent signaling
Godeny et al., Am J Physiol Cell Physiol 2006
:
ANG II-induced cell proliferation is dually mediated by
c-Src/Yes/Fyn regulated
ERK1/2 activation in the cytoplasm and PKCzeta controlled ERK1/2 activity within the nucleus ... We next investigated whether a loss of either
c-Src/Yes/Fyn or PKCzeta signaling
affected ERK1/2 nuclear translocation and cell proliferation in response to ANG II
Shiraishi et al., Exp Cell Res 2008
:
Transfection of interfering constructs shows that the LHR mediated activation of
Fyn in MA-10 cells is
necessary for the phosphorylation of the EGFR and
ERK1/2 in I-10 cells