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GAPDH — PARP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kiss et al., Mem Inst Oswaldo Cruz 2005
(Diabetes Complications) :
On the other hand,
PARP activation
results in inhibition of
GAPDH by poly-ADP-ribosylation
Devalaraja-Narashimha et al., J Am Soc Nephrol 2009
(Ischemia) :
Using in vitro and in vivo models, under hypoxic conditions, we detected poly ( ADP-ribosyl ) ation and reduced activity of GAPDH ; inhibition of
PARP-1 activity
restored GAPDH activity and ATP levels
Szabo et al., Br J Pharmacol 2009
(Diabetic Angiopathies) :
PARP mediated poly ( ADP-ribosyl ) ation and
inhibition of
glyceraldehyde-3-phosphate dehydrogenase importantly contributes to the development of diabetic vascular complications : it induces activation of multiple pathways of injury including activation of nuclear factor kappa B, activation of protein kinase C and generation of intracellular advanced glycation end products