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GJA1 — MAPK6
Text-mined interactions from Literome
Hossain et al., J Cell Physiol 1999
:
Since many of these agents activate additional protein kinases, our present study examined whether activation of
MAPK was
sufficient for
Cx43 phosphorylation and GJC blockade
Carystinos et al., Mol Pharmacol 2003
:
This study provides evidence that the transcriptional
up-regulation of
Cx43 by
Ras-Raf-MAPK is mediated via the interaction of a novel Cx43 promoter element with a protein complex that contains both HSP90 and c-Myc
Kalma et al., Endocrinology 2004
:
We show herein that LH inhibits
Cx43 expression by reducing its rate of translation and that this effect is
mediated by both PKA and
MAPK
Chung et al., Toxicological sciences : an official journal of the Society of Toxicology 2006
:
Previously, we reported that 2,2'-dichlorobiphenyl ( 2,2'-DCB ) -induced decreases of amplitude and synchronization of uterine contractions are dependent on
MAPK induced phosphorylation of
Connexin43 (Cx43) and inhibition of myometrial gap junctions ... Furthermore, cotreatment with SOD or Def was unable to prevent 2,2'-DCB induced phosphorylation of
Cx43 ,
activation of
MAPK , and inhibition of myometrial gap junctions
Wang et al., BMC cell biology 2011
:
AGE-BSA down-regulated
Cx43 expression in HAEC, mainly through reduced Cx43 transcription, and the process
involved activation of ERK and p38
MAPK
Johnstone et al., Circ Res 2012
(Atherosclerosis) :
Coimmunoprecipitation studies in primary VSMC isolated from Cx43 wild-type ( Cx43 ( +/+ ) ) and Cx43 null ( Cx43 ( -/- ) ) mice and analytic size exclusion studies of purified proteins identify that interactions between cyclin E and
Cx43 requires Cx43
MAPK phosphorylation
Negoro et al., Scientific reports 2013
(Disease Models, Animal...) :
SB203580 ( p38
MAPK inhibitor )
prevented IL-1ß induced
Cx43 upregulation
Hossain et al., J Cell Physiol 1998
:
Platelet derived growth factor induced disruption of gap junctional communication and phosphorylation of
connexin43 involves protein kinase C and
mitogen activated protein kinase