Gene interactions and pathways from curated databases and text-mining

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GNRH1 — IL1B

Text-mined interactions from Literome

Kang et al., J Neuroendocrinol 2000 : Effect of interleukin-1beta on gonadotropin releasing hormone (GnRH) and GnRH receptor gene expression in castrated male rats ... This study was undertaken to elucidate the effect of IL-1beta on GnRH as well as GnRH receptor (GnRHR) gene expression in the preoptic area
Huang et al., J Assist Reprod Genet 2001 : The quantitative level of GnRH mRNA expression regulated by IL-1 beta in Vero cells was determined by quantitative competitive PCR ( QC PCR ) with standard curve methodology
Huang et al., Fertil Steril 2003 : To investigate the role of interleukin-1beta (IL-1beta) in regulating GnRH mRNA expression in cultured human endometrial stromal cells using a modified semiquantitative competitive reverse transcription and polymerase chain reaction ( PCR ) ... Interleukin-1beta mediated regulation of stromal cell GnRH mRNA expression was determined by quantitative competitive PCR ... Recombinant IL-1 receptor antagonist and anti-IL-1beta antibody attenuated the increase of gene expression of GnRH initiated by IL-1beta
Oktenli et al., Hum Reprod 2004 (Acute Disease...) : Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis : suppressive effect of interleukin-1 beta on the secretion of GnRH
Kalra et al., Endocrinology 1990 : Both IL-1 alpha and IL-1 beta , at concentrations of 0.1 nM and higher, significantly suppressed LHRH release in vitro from the medial basal hypothalamus-preoptic area
Kalra et al., Endocrinology 1990 : These results suggest that IL-1 alpha and IL-1 beta inhibit LHRH-LH release by stimulating the activity of hypothalamic endogenous opioid peptide systems
Yamaguchi et al., Acta Endocrinol (Copenh) 1990 : Interleukin 1 beta and tumour necrosis factor alpha stimulate the release of gonadotropin releasing hormone and interleukin 6 by primary cultured rat hypothalamic cells ... The abilities of recombinant human interleukin 1 beta and tumour necrosis factor alpha to induce release of GnRH and interleukin 6 from primary culture of rat hypothalamic cells were examined ... Both interleukin 1 beta and tumour necrosis factor alpha caused significant stimulation of GnRH secretion from the hypothalamic cells within 5 min ... These results suggest that interleukin 1 beta and tumour necrosis factor alpha stimulate the secretions of GnRH and interleukin 6 in the hypothalamus, and that these cytokines may be involved in the mechanism of GnRH secretion in the hypothalamus
Rivest et al., Brain Res 1993 : In contrast, 50 ng IL-1 beta was less effective ( P < 0.05 ) when administered at 08.30 h, and totally without effect when infused at 14.30 h. Infusion of 50 ng IL-1 beta also markedly suppressed the hypothalamic release of LH-RH in proestrus rats bearing a push-pull cannula into the ME, and significantly decreased plasma LH levels in both gonadectomized male and female rats