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GP5 — PTGS2

Text-mined interactions from Literome

Yagi et al., Planta Med 2003 : Radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane A2 synthase from aloe vera gel
Ray et al., J Virol 2004 : Immediate-early protein IE180, major capsid protein VP5, and glycoprotein expression were slightly reduced in the presence of COX-2 inhibitors, but expression of the early protein EP0 was not affected by COX inhibition
Alvarez et al., J Neurochem 2005 (Neuroblastoma) : Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism
Güven et al., J Endod 2007 : Recent data from the medical literature indicates that cyclooxygenase-2 (COX-2) plays a key role in the production of vascular endothelial growth factor ( VEGF ), a glycoprotein that has the ability to increase the permeability of blood vessels and to induce angiogenesis
Fantappiè et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : Because COX-2 induces P-glycoprotein expression, we evaluated the effect of celecoxib, a specific inhibitor of COX-2 activity, on P-glycoprotein mediated resistance to apoptosis in cell lines expressing multidrug resistant ( MDR ) phenotype
Alvarez et al., Neuromolecular Med 2007 (Astrocytoma) : HIV-1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in astrocytoma cells through a nuclear factor-kappaB dependent mechanism
Lee et al., Inflamm Res 2009 (Inflammation...) : In addition, ZPDC glycoprotein ( 200 microg/ml ) not only diminished the production of superoxide anion, hydrogen peroxide, and nitric oxide, but also suppressed the expression of pro-inflammatory cytokines ( IL-1 beta, IL-6, and TNF-alpha ) and proteins ( iNOS, COX-2 , and MMP-9 ) in LPS- stimulated RAW 264.7 cells
Zibell et al., Neuropharmacology 2009 (Status Epilepticus) : Prevention of seizure induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition ... Based on these data, we hypothesized that selective inhibition of COX-2 could prevent seizure induced P-glycoprotein up-regulation ... In the present study, we found that the highly selective COX-2 inhibitors, NS-398 and indomethacin heptyl ester, blocked the glutamate induced increase in P-glycoprotein expression and transport function in isolated rat brain capillaries ... Importantly, consistent with this, the COX-2 inhibitor, celecoxib, blocked seizure induced up-regulation of P-glycoprotein expression in brain capillaries of rats in vivo ... To explore further the role of COX-2 in signaling P-glycoprotein induction, we analyzed COX-2 protein expression in capillary endothelial cells in brain sections from rats that had undergone pilocarpine induced seizures and in isolated capillaries exposed to glutamate and found no change from control levels
van Vliet et al., Neuropharmacology 2010 (Chronic Disease...) : COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats ... Therefore, we tested the effect of specific cyclooxygenase-2 inhibition on P-glycoprotein expression in two different status epilepticus models
Oh et al., J Appl Toxicol 2010 (Carbon Tetrachloride Poisoning...) : We also found that MIL glycoprotein reduced the activity of COX-2 and expression of TNF-a and IL-1 beta in liver from CCl ( 4 ) -treated mice
Oh et al., Inflammation 2011 (Hypersensitivity...) : We also found that the CTB glycoprotein reduced arachidonic acid release, COX-2 expression, and AP-1 transcriptional activation through p38 MAPK phosphorylation in DEHP treated RBL-2H3 cells
Lee et al., Mol Cell Biochem 2012 : Taken together, these data indicate that the SJSZ glycoprotein prevents expression of COX-2 , iNOS, and IL-1ß by blocking NF-?B and MAPKs in Cr ( VI ) -induced BNL CL.2 cells