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GRAP2 — TNF
Text-mined interactions from Literome
Hashimoto et al., Biochem Biophys Res Commun 1999
:
We examined the regulatory role of a reduction/oxidation ( redox ) control protein, thioredoxin (TRX), in
tumor necrosis factor-alpha (TNF-alpha) induced p38 MAP kinase activation and
p38 MAP kinase mediated cytokine expression utilizing TRX transfected murine L929 cells ( TRX14 )
De Keulenaer et al., Arterioscler Thromb Vasc Biol 2000
:
In this study, we show that
TNF-alpha induces a parallel phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and
p38 mitogen activated protein kinase ( p38MAPK ) and increases MCP-1 mRNA expression in cultured VSMCs. Inhibition of ERK1/2 but not p38MAPK caused a partial attenuation of MCP-1 induction ( 43+/-10 % inhibition )
Hashimoto et al., Allergy 2000
:
However, a regulatory role of intracellular glutathione ( GSH ) in
TNF-alpha induced
p38 MAP kinase
activation and p38 MAP kinase mediated RANTES production has not been determined ... The results showed that 1 ) NAC attenuated TNF-alpha induced p38MAP kinase activation and RANTES production 2 ) SB 203580 as the specific inhibitor of p38 MAP kinase activity attenuated TNF-alpha induced RANTES production 3 ) BSO facilitated
TNF-alpha induced
p38 MAP kinase activation and RANTES production 4 ) SB 203580 attenuated BSO mediated facilitation of TNF-alpha induced RANTES production ... These results indicated that
TNF-alpha induced
p38 MAP kinase
activation and p38 MAP kinase mediated RANTES production by human pulmonary vascular endothelial cells are inversely regulated by intracellular GSH levels
De et al., J Immunol 2000
:
Although exogenous hsp27 stimulation activated all three monocyte mitogen activated protein kinase pathways ( extracellular signal related kinase ( ERK ) 1/2, c-Jun N-terminal kinase, and p38 ), only p38 activation was sustained and required for hsp27 induction of monocyte IL-10, while both ERK 1/2 and
p38 activation were
required for induction of
TNF-alpha when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059
Birrell et al., Eur Respir J 2000
(Pneumonia...) :
SB 203580 is a pyridinyl imidazole compound which
inhibits the release of pro-inflammatory cytokines, such as
tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in vitro and in vivo by inhibiting
p38 mitogen activated protein kinase ( MAPK )
Hashimoto et al., Clin Exp Allergy 2001
:
These results indicate that cellular redox regulated by GSH is critical for
TNF-alpha induced
p38 MAP kinase
activation and p38 MAP kinase mediated RANTES production by human BECs ... The results showed that : NAC attenuated TNFalpha induced p38 MAP kinase activation and RANTES production ; SB 203580 as the specific inhibitor of p38 MAP kinase activity attenuated TNF-alpha induced RANTES production ; BSO facilitated
TNF-alpha induced
p38 MAP kinase activation and RANTES production ; SB 203580 attenuated BSO mediated facilitation of TNF-alpha induced RANTES production ; and the intracellular GSH increased in NAC treated cells, whereas the intracellular GSH was reduced in BSO treated cells
Nakada et al., Anticancer Res 2001
(MAP Kinase Signaling System) :
TNF-alpha induced apoptosis was
potentiated by the inhibition of either MEK alone, or MEK plus
p38MAPK , suggesting that the MAPK pathway may be a promising target for cancer therapy
Surapisitchat et al., Proc Natl Acad Sci U S A 2001
(MAP Kinase Signaling System) :
TNF-alpha or IL-1 alone
activated ERK1/2,
p38 , and JNK maximally at 15 min in HUVEC
Li et al., J Neurosci Res 2001
(MAP Kinase Signaling System) :
Lipopolysaccharide (LPS) treatment of a microglial cell line ( N9 )
induced a time dependent activation of both
p38 mitogen activated protein kinase ( p38 MAPK ) and nuclear factor-kappaB (NFkappaB), with consequent increases in interleukin-1alpha (IL-1alpha),
tumor necrosis factor-alpha (TNF-alpha) , and nitric oxide ( NO ) production
Yi et al., Int Immunol 2001
:
Both extracellular receptor kinase (ERK) and
p38 can
regulate TNF-alpha gene transcription induced by CpG DNA
Webb et al., J Dent Res 2002
(Osteosarcoma) :
Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that
p38 MAPK
activation by
TNF-alpha enhanced IL-6 gene expression, and that the p38 MAPK-responsive region resided in the proximal 260-bp segment
Lu et al., Chin J Traumatol 2001
:
Regulative
effect of
P38MAPK on release of
TNFalpha and NO from alveolar macrophages under endotoxin stimulation ... SB203580, a specific inhibitor of P38MAPK, was used with gradient concentration to evaluate the regulative
effect of
P38MAPK on the release of
TNFalpha and NO from AM
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by
tumor necrosis factor , interleukin-1alpha, or gamma-interferon
Guo et al., J Biol Chem 2003
(Inflammation) :
This strategy established the
requirement for
p38 activity for the lipopolysaccharide stimulated production of IL-10, IL-1beta, and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and
TNFalpha stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9
Schäfers et al., J Neurosci 2003
(Neuralgia) :
In DRG,
p38 activation is blocked by systemic
TNF inhibition
Song et al., J Clin Immunol 2003
(Tuberculosis) :
The role of mitogen activated protein kinase ( MAPK ) pathways in the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, IL-8, and monocyte chemotactic protein-1 (MCP-1) was investigated in human monocytes that were infected with Mycobacterium tuberculosis H37Rv. Analysis of extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and p38 kinase showed rapid phosphorylation of both subfamilies in response to M. tuberculosis H37Rv. Using highly specific inhibitors of p38 ( SB203580 ) and of MAPK kinase-1 ( U0126 and PD98059 ), we found that both
p38 and ERK were
essential for M. tuberculosis H37Rv induced
TNF-alpha production, whereas activation of the p38 pathway, but not that of ERK, was essential for M. tuberculosis H37Rv induced IL-10 production
Gee et al., J Biol Chem 2003
:
Taken together, our results suggest that
TNF-alpha induced
p38 MAPK
activation may regulate the induction of functionally active HA-binding form of CD44 by activating sialidase in LPS stimulated human monocytic cells
Liacini et al., Exp Cell Res 2003
:
TNF-alpha rapidly
activated phosphorylation of extracellular signal regulated kinases ( ERKs ),
p38 , and c-jun N-terminal kinase ( JNK ) mitogen activated protein ( MAP ) kinases in human chondrocytes
Lee et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
In transfection studies, RIP1 and TRAF2 stimulate
p38 MAP kinase activation, and dominant negative forms of RIP1 and TRAF2
inhibit TNF-alpha induced p38 MAP kinase activation ... We found
TNF-alpha induced
p38 MAP kinase activation and interleukin-6 (IL-6) production impaired in rip1 ( -/- ) murine embryonic fibroblasts (MEF) but unaffected in traf2 ( -/- ) MEF
Iijima et al., Immunology 2003
:
In the present study, we analysed the
effects of
tumour necrosis factor-alpha (TNF-alpha) and 2,4-dinitrochlorobenzene ( DNCB ) on phenotypic maturation and
p38 mitogen activated protein kinase ( MAPK ) activity, using a murine DC line
Tudan et al., Cell Signal 2004
:
CPPD crystal associated repression of
TNF-alpha induced activation of neutrophil apoptosis as determined by DNA fragmentation correlated with the CPPD crystal
mediated inhibition of
p38 kinase activity, probably through crystal inhibition of caspase 3
Kim et al., Toxicol Appl Pharmacol 2004
(Necrosis) :
P38 mediated caspase activation regulates mercury induced apoptosis and p38 mediated
TNFalpha regulates necrosis in these cells
Lee et al., J Biol Chem 2004
:
The kinase activity of Rip1 is not required for
tumor necrosis factor-alpha induced IkappaB kinase or
p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2
Bouaouina et al., J Immunol 2004
:
Finally,
p38 MAPK
activation by
TNF was blocked by diphenylene iodonium, an inhibitor of flavoprotein oxidoreductase, and by the free radical scavenger N-acetylcystein
Hernandez et al., Diabetologia 2004
(Insulin Resistance) :
Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing
TNF-alpha induction of
p38 and p42/p44 mitogen activated protein kinases
Woo et al., Am J Physiol Lung Cell Mol Physiol 2005
:
In addition, TNF-alpha was shown to induce the expression of VCAM-1 in a p38 kinase dependent manner ; also,
TNF-alpha induced
p38 kinase activation was blocked by inhibition of PKCdelta, suggesting that p38 kinase is apparently situated downstream of PKCdelta in the TNF-alpha signaling pathway to VCAM-1 expression
Murata-Ohsawa et al., Int J Mol Med 2004
:
The
TNF-alpha induced activation of c-Jun N-terminal kinase (JNK),
p38 , and NF-kappaB was not affected by Delta-1 stimulation
Roach et al., Infect Immun 2005
:
The
TNF-alpha production was
dependent on both
p38 and extracellular signal regulated kinase 1/2 ( ERK 1/2 ) activation
Li et al., J Biol Chem 2005
(Arteriosclerosis...) :
However,
MKK3/p38 signaling was specifically
involved in
TNF-alpha induction, and Erk1/2 signaling was required for IL-6
Lokuta et al., J Leukoc Biol 2005
(Asthma...) :
TNF-alpha induces a more than tenfold increase in
p38 mitogen activated protein kinase ( MAPK ) but not extracellular signal regulated kinase phosphorylation
Cao et al., Am J Physiol Gastrointest Liver Physiol 2005
:
ERK1/2 stimulated TNF-alpha production via activation of NF-kappaB, whereas
p38 promoted
TNF-alpha production by stabilizing TNF-alpha mRNA
Shen et al., Life Sci 2005
:
Recombinant constitutively active adenovirus ( Ad ) -MKK6 and-MKK7
increased TNF-alpha production in KCs with activation of
P38 and JNK without any change by Ad-MEK1 delivery ... The delivery of Ad-MKK6 and-MKK7, but not Ad-MEK1,
increased TNF-alpha production in KCs of Zucker rats with activation of
P38 and JNK
Komine et al., J Invest Dermatol 2005
:
Inhibitors for nuclear factor kappa B (NFkappaB), parthenolide, and Bay 11-7085, and an inhibitor of
p38 , SB202190,
inhibited TNFalpha- and IFNgamma induced production of CCL17 by HaCaT KC. Surprisingly, an inhibitor of epidermal growth factor receptor tyrosine kinase, PD153035, enhanced the production of CCL17 in HaCaT KC. Roxithromycin ( RXM ), a 14-membered ring macrolide, suppressed CCL17 production by HaCaT KC induced by IFNgamma and TNFalpha
Kobayashi et al., Exp Dermatol 2005
:
We show ( i ) UV induced up-regulation of TNF-alpha mRNA and protein expression in keratinocytes ; ( ii ) cells treated with KTI before UV irradiation showed a significantly lower accumulation of
TNF-alpha protein in a dose dependent manner and a reduced UV-induced up-regulation of TNF-alpha mRNA expression ; ( iii ) KTI inhibited the induction of TNF-alpha target molecules interleukin-1beta (IL-1beta) and IL-6 proteins ; ( iv ) UV irradiation transiently activated c-Jun N-terminal kinase (JNK) and Akt signaling but only weakly activated extracellular signal regulated kinase ( ERK ) and p38 ; ( v ) KTI specifically
inhibited UV-induced activation of ERK, JNK, and
p38 , but not Akt ; ( vi ) treatment of cells with SP600125, a pharmacological inhibitor of JNK, predominantly suppressed UV-induced up-regulation of TNF-alpha expression ; and ( vii ) KTI did not enhance suppression of UV-induced JNK phosphorylation by SP600125
Lee et al., Infect Immun 2005
:
TNF-alpha and NOS2 levels correlated with and were
dependent on the activation of mitogen activated protein kinases ( MAPKs )
p38 and extracellular signal regulated kinase 1/2 ( ERK1/2 )
Resch et al., Endocrinology 2006
(Second Messenger Systems) :
An inhibitor of
p38 activation ( SB203580 )
had no effect on
TNFalpha- or IL-1beta stimulated PAPP-A expression
Sheng et al., J Leukoc Biol 2005
(Encephalitis...) :
TNF-alpha treatment
induced p38 mitogen activated protein kinase ( MAPK ) phosphorylation in NPCs, and SB202190, an inhibitor of p38 MAPK, blocked TNF-alpha induced chemokine production
Trujillo et al., J Clin Endocrinol Metab 2006
(Obesity) :
The
TNF + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally
blocked by
p38 MAPK inhibitors
Inoue et al., Proc Natl Acad Sci U S A 2006
(Arthritis, Experimental) :
These studies showed that
TNF-alpha increased phosphorylation of
p38 in WT cultured synoviocytes but that p38 activation, IL-1beta, and IL-6 expression were markedly lower in MKK3 ( -/- ) synoviocytes
Higashimoto et al., Cytokine 2006
(Chromosome Aberrations) :
TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK,
p38 and caspase pathways
Chen et al., Shock 2006
(Burns...) :
TNF-alpha and PAF
increased p38 phosphorylation of neutrophil in WT but not that in Tnfrsf1a-/- mice ... Taken together with the
TNF-alpha dependent
p38 and NF-kappaB activation in primed neutrophil, we conclude that thermal injury induced priming effect of polymorphonuclear neutrophil is TNF-alpha and p38 dependent
Lee et al., Scand J Immunol 2006
(Tuberculosis) :
Further, the activation of
p38 mitogen activated protein kinase and extracellular signal regulated kinase was
required for the induction of
TNF-alpha and IL-6 by MTB12, as well as by the 30-kDa Ag
Olson et al., Infect Immun 2007
:
B. burgdorferi induced
TNF-alpha production is also
dependent on the activation of
p38 mitogen activated protein ( MAP ) kinase
Fürst et al., FASEB J 2007
:
Importantly, Dex is able to increase the expression of MKP-1, which causes an inactivation of
TNF-alpha induced
p38 MAPK and mediates inhibition of E-selectin expression
Chen et al., Am J Physiol Cell Physiol 2007
(Disease Models, Animal...) :
To fully evaluate the
role of
TNF-alpha in myogenic activation of
p38 , we tried to determine whether p38 activation in differentiating myoblasts requires autocrine TNF-alpha, and whether forced activation of p38 rescues impaired myogenesis and regeneration in the p55 ( -/- ) p75 ( -/- ) soleus
Kunisch et al., Ann Rheum Dis 2007
(Arthritis, Rheumatoid...) :
Predominant
activation of MAP kinases and pro-destructive/pro-inflammatory features by
TNF alpha in early-passage synovial fibroblasts via TNF receptor-1 : failure of
p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis
Zhan et al., J Cell Sci 2007
(Mechanotransduction, Cellular) :
Disrupting
TNF-alpha signaling by TNF-alpha neutralizing antibody or knocking out TNF-alpha receptors
blocked stretch activation of
p38 , but not ERK1/2, JNK or AKT
Nah et al., FEBS Lett 2007
(Osteoarthritis) :
The stimulatory effect of AGE-BSA on MMP-1, -3, and -13 were reversed by treatment with specific JNK, p38 inhibitors, suggesting JNK and
p38 are
involved in AGE-BSA induced MMPs and
TNF-alpha
Li et al., Endocrinology 2007
:
TNF-alpha increased
p38 MAPK phosphorylation, potently stimulated IRS-1 serine phosphorylation, and blunted insulin stimulated IRS-1 tyrosine and Akt phosphorylation and eNOS activity
Sodhi et al., Glycoconj J 2007
:
Pharmacological inhibitor of tyrosine kinase, PI3 kinase, protein kinase C, p42/44,
p38 , JNK and intracellular calcium immobilizing agent down
regulated the WGA induced expression of cytokines
TNF-alpha , IL-1beta, IL-12 and IFN-gamma
Arandjelovic et al., J Neurochem 2007
(Constriction, Pathologic...) :
MAC inhibited
TNF-alpha induced
p38 mitogen activated protein kinase
activation and cell death in cultured Schwann cells
Xue et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid...) :
Furthermore, APC directly suppressed the production of
tumor necrosis factor (TNF) and the
activation of NF-kappaB and MAP kinase
p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9, suggesting that APC inhibits MMP-9 by blocking TNF, NF-kappaB, and p38
Stähli et al., Arterioscler Thromb Vasc Biol 2007
:
Ouabain did not affect
TNF-alpha induced activation of the MAP kinases
p38 , extracellular signal regulated kinase ( ERK ), and c-Jun terminal NH ( 2 ) kinase ; activation of Akt and p70S6 kinase remained unaltered as well
Takada et al., Mol Pharmacol 2008
(Neoplasms) :
Flavopiridol suppresses
tumor necrosis factor induced
activation of activator protein-1, c-Jun N-terminal kinase,
p38 mitogen activated protein kinase ( MAPK ), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells
Quante et al., Am J Respir Cell Mol Biol 2008
:
Corticosteroids rapidly up-regulate MKP-1 in a time dependent manner ( 44.6 +/- 10.5-fold increase after 24 h treatment with dexamethasone ; P < 0.05 ), and MKP-1 up-regulation was temporally related to the inhibition of
TNF-alpha induced
p38 MAPK phosphorylation
Hung et al., Eur J Pharmacol 2008
:
On the other hand, lycopene did not affect
TNF-alpha induced
p38 and extracellular matrix regulated kinase1/2 ( ERK1/2 ) phosphorylation and interferon-gamma (IFN-gamma) induced signaling, suggesting that lycopene primarily affects TNF-alpha induced NF-kappaB signaling pathway
Nakao et al., Innate Immun 2008
:
The H ( 2 ) O ( 2 ) induced
TNF-alpha production was
prevented by inhibitors of
p38 and stress activated protein kinase ( SAPK/JNK ), and H ( 2 ) O ( 2 ) induced the phosphorylation of p38 and SAPK
Yomogida et al., Int J Mol Med 2008
:
Furthermore, glucosamine inhibited the
TNF-alpha induced phosphorylation of
p38MAPK and NF-kappaB p65, and the nuclear translocation of NF-kappaB in the cells
Clarke et al., Mol Pharmacol 2008
(Lung Neoplasms) :
PMA stimulated nSMase2 translocation was independent of p38 MAPK, and neither PKC inhibitors nor small interfering RNA had significant effects on
TNF stimulated
p38 MAPK activation, indicating that PKC-delta does not act through p38 MAPK in regulating nSMase2
Itatsu et al., Liver Int 2009
(Cholangiocarcinoma) :
These data suggest that
TNF-alpha/TNF-R1 interaction
leads to the phosphorylation of Erk1/2 and
p38MAPK and nuclear translocation of NF-kappaB, which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1
Lee et al., Int Immunopharmacol 2008
(Urinary Bladder Neoplasms) :
Moreover,
p38 MAP kinase mediated MMP-9 gene regulation in
response to
TNF-alpha is involved in the NF-kappaB response element in 5637 cells
Navas et al., Leukemia & lymphoma 2008
(Inflammation...) :
Furthermore,
p38 inhibition
diminishes the expression of
TNFalpha or IL-1beta induced proinflammatory chemokines in BM stromal cells
Huang et al., Cell Mol Immunol 2008
(Calcium Signaling) :
Treatment with Gab2 siRNA significantly decreased Gab2 expression, inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine, reduced the production of IL-4 and
TNF-alpha and
inhibited the phosphorylation of Akt, PKCdelta and
p38 mitogen activated protein kinase ( MAPK )
Suri et al., Biomaterials 2009
(Adenocarcinoma...) :
When co-assembled in a ratio of 1 : 10 microM these composite RNTs ( referred to as RGDSK/K-RNTs ) rapidly induced phosphorylation of
P38 mitogen activated protein kinase ( MAPK ) within 2 min. Higher concentrations of RGDSK/K-RNTs ( > 10 : 100 microM )
resulted in a P38 MAPK dependent increase in secretion of
TNF-alpha
Fu et al., Wound Repair Regen 2009
(Disease Models, Animal...) :
TNF-alpha at 50 microg/L
increased the expression of phospho-ERK and
phospho-p38 , and SB203580, but not PD98059, could suppress the chemotaxis effect and up-regulation of ICAM-1 induced by TNF-alpha in MSCs ( p < 0.05 )
Folco et al., J Biol Chem 2009
(Inflammation...) :
We demonstrate that pretreatment of these cells with adiponectin inhibits phosphorylation of nuclear factor kappaB inhibitor ( IkappaB ), c-Jun N-terminal kinase (JNK), and
p38 mitogen activated protein kinase ( MAPK ),
induced by either lipopolysaccharide (LPS) or
tumor necrosis factor (TNF) alpha, as well as STAT3 phosphorylation induced by interleukin-6 (IL6)
Fu et al., J Vet Med Sci 2009
(Inflammation) :
Vaspin did not inhibit the
TNF-alpha ( 20 min )
activation of JNK,
p38 and NF-kappaB, but only slightly inhibited Akt
Liu et al., Proc Natl Acad Sci U S A 2009
:
Neither JNK1 activation by IL-1beta or UV nor
TNF-alpha induced
activation of
p38 , ERK, or IkappaB kinase complex is affected by the loss of Miz1
Huang et al., Br J Cancer 2009
:
This impaired A20 induction in E1A/Ras MEFs was not because of the stabilisation of p53 or a defective
TNF induced
p38 and Jun N-terminal kinase (JNK) signalling
Rakkestad et al., Inhal Toxicol 2010
(Inflammation) :
MEHP also
induced phosphorylation of MAPK
p38 , while the p38 inhibitor SB 202190 reduced MEHP induced
TNF-alpha , suggesting a p38 dependent cytokine production
Stjernberg-Salmela et al., Rheumatology (Oxford) 2010
(Familial Mediterranean Fever) :
Because the pathomechanism of TRAPS may involve aberrant TNF mediated intracellular signalling, we examined phosphorylation levels of nuclear factor kappaB (NF-kappaB) and
p38 in
response to
TNF in 10 patients with three different TNFRSF1A mutations ( C73R, C88Y and F112I )
Hui et al., Anat Rec (Hoboken) 2010
:
In addition, ACSO also inhibited
TNF-alpha induced phosphorylation of JNK, ERK1/2 and IkappaB, but not
p38
Soegaard-Madsen et al., Br J Dermatol 2010
(Psoriasis) :
The rapid inhibition of p38 MAPK by adalimumab in lesional psoriatic skin preceded clinical and histological improvements, demonstrating an association between
TNF-a neutralization and
p38 MAPK
inhibition
Hirata et al., Biol Pharm Bull 2010
:
A
p38 inhibitor, SB203580, also
inhibited the
TNFalpha production dose-dependently
Gallelli et al., Int J Immunopathol Pharmacol 2010
:
Effects of budesonide on
P38 MAPK activation, apoptosis and IL-8 secretion,
induced by
TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells ...
TNF-alpha induced a significant increase in
p38 MAPK phosphorylation
Baregamian et al., Oxidative medicine and cellular longevity 2009
(Enterocolitis, Necrotizing...) :
Tumor necrosis factor-alpha and apoptosis signal regulating kinase 1
control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal
kinase/p38 phosphorylation during necrotizing enterocolitis
Ibrahim et al., Molecular vision 2010
(Diabetes Mellitus, Experimental...) :
Genistein represses the release of
TNF-a and significantly
inhibits ERK and
P38 phosphorylation in activated microglial cells by acting as a tyrosine kinase inhibitor
Bayardo et al., Clin Exp Immunol 2012
(Celiac Disease) :
The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K), while c-Jun N-terminal kinase (JNK) and
p38 mitogen activated protein kinase ( MAPK ) were
required for
TNF-a activation
Tsou et al., J Cell Biochem 2012
(Osteoarthritis) :
Stimulation of cells with
TNF-a enhanced ASK1, JNK, and
p38 activation
Nasimian et al., Inflamm Res 2013
:
NF-kB, JNK,
p38 and ERK specific inhibitors significantly
reduced the production of
TNF-a and IL-6 in macrophages stimulated with palmitate and also PTP1B knockdown cells
Takekawa et al., EMBO J 1997
:
Overexpression of a dominant negative MTK1 mutant [ MTK1 ( K/R ) ] strongly inhibited the activation of the p38 pathway by environmental stresses ( osmotic shock, UV and anisomycin ), but not the
p38 activation by the cytokine
TNF-alpha
Carpentier et al., FEBS Lett 1998
:
Here, we have studied the
role of several
TNF receptor associated proteins and caspases in
p38 MAPK activation by TNF