Zage et al., Pediatr Blood Cancer 2012
(Neuroblastoma) :
The HES2 and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines, and HES gene expression could be induced through treatment with decitabine
Kageyama et al., Int J Biochem Cell Biol 1997
:
Thus, HES1 regulates brain and eye morphogenesis by inhibiting premature neuronal differentiation, and the down-regulation of HES1 expression at the right time is required for normal development of the nervous system