Gene interactions and pathways from curated databases and text-mining

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HGF — SRC

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Manganini et al., Oncogene 2000 : Indeed, TGF beta2 inhibited HGF effects because it prevented HGF induced MAP kinase activation and tyrosine phosphorylation of Src
Hung et al., J Biol Chem 2001 (Mammary Neoplasms, Experimental) : Expression of activated c-Src in SP1 cells increased transcription from the HGF promoter and expression of HGF mRNA and protein, while dominant negative c-Src had the opposite effect ... Coexpression of activated c-Src and Stat3 synergistically induced strong HGF promoter activity in SP1 cells, as well as in a nonmalignant epithelial cell line, HC11 ( HGF negative )
Elliott et al., Can J Physiol Pharmacol 2002 (Breast Neoplasms...) : We have recently demonstrated that sustained activation or hyper-activation of c-Src and Stat3, which occurs in invasive breast cancer, can stimulate strong expression of HGF in carcinoma cells
Pongchairerk et al., World J Gastroenterol 2005 (Cholangiocarcinoma) : Autophosphorylated Src , induced by HGF , mediates Src kinase activation, which subsequently phosphorylates its substrate, FAK, and signals to cell proliferation and invasion
Kanda et al., Biochem Biophys Res Commun 2006 : Stable expression of kinase-inactive Src in MSS31 cells inhibited HGF induced activation of Src as well as capillary morphogenesis ... These results suggest that HGF induces capillary morphogenesis of endothelial cells through Src
Sam et al., Molecular cancer 2007 (Breast Neoplasms) : A novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells ... Src/Stat3 expression did activate HGF transcription in OVCAR3 cells, but this effect was not mediated by the Stat3 site at nt-95 ... These results suggest that human breast cells are a uniquely permissive environment for HGF transactivation by Src/Stat3 which may allow for the inappropriate activation of HGF transcription during the early stages of breast transformation
Watanabe et al., Mol Cancer Res 2009 (Sarcoma, Synovial) : In response to hepatocyte growth factor stimulation, Crk prominently induced the tyrosine phosphorylation of Grb2 associated binder 1 through activation of Src and focal adhesion kinase, and the Src family kinase inhibitor PP2 almost completely inhibited the proliferation of SYO-1 cells
Singhal et al., Int J Biochem Cell Biol 2011 : Inhibition of I?B kinase is mediated by hepatocyte growth factor induced activation of c-Src ... Proximal signaling events induced in dendritic cells by hepatocyte growth factor include a physical association of c-Src with the hepatocyte growth factor receptor c-MET and concomitant activation of c-Src ... Notably, hepatocyte growth factor stimulated c-Src activation results in induction of phosphatidylinositol 3-kinase complexes p85a/p110a and p85a/p110d, which is required for activation of mammalian target of rapamycin, and consequent inhibition of I?B kinase and nuclear factor-?B activation
Singhal et al., J Biol Chem 2011 : Notably, Btk activation is necessary for HGF induced association of c-Src and PI3K with c-MET
Chen et al., PloS one 2012 : Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src , and AP-1 signaling pathway ... Stimulation of osteoblasts with HGF enhanced PI3K, Akt, and c-Src activation
Grano et al., Proc Natl Acad Sci U S A 1996 (Bone Neoplasms...) : In osteoclasts, HGF receptor activation is followed by increase in intracellular Ca2+ concentration and by activation of the pp60c-Src kinase
Rahimi et al., J Biol Chem 1998 (Mammary Neoplasms, Experimental) : Taken together, our data strongly suggest that HGF induced association of c-Src with Met and c-Src activation play a critical role in HGF induced cell motility and anchorage independent growth of mammary carcinomas and further support the notion that the presence of paracrine and autocrine HGF loops contributes significantly to the transformed phenotype of carcinoma cells