Gene interactions and pathways from curated databases and text-mining

◀ Back to BRAF

BRAF — HIF1A

Text-mined interactions from Literome

Kumar et al., Cancer Res 2007 (Melanoma) : Here, we report that mutant BRAF ( V600E ) increases HIF-1alpha expression in melanoma cells ... Stable suppression of mutant BRAF ( V600E ) or both wild-type and mutant BRAF ( V600E ) by RNA interference in melanoma cells resulted in significantly decreased HIF-1alpha expression ... Pharmacologic inhibition of BRAF by BAY 43-9006 also resulted in decreased HIF-1alpha expression
Kikuchi et al., Cancer Res 2009 (Anoxia...) : Many hypoxic responses are mediated by hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, and we sought to define the roles of mutant KRAS and BRAF in the induction of HIF-1alpha and HIF-2alpha in colon cancer cells ... Ectopic expression of mutant K-ras in Caco2 cells enhanced the hypoxic induction of only HIF-1alpha, whereas mutant BRAF enhanced both HIF-1alpha and HIF-2alpha ... Although BRAF regulated mRNA levels of both HIF-1alpha and HIF-2alpha, knockdown of BRAF or treatment with the MEK inhibitor PD98059 impaired the translation of only HIF-2alpha