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HMGB1 — TLR7

Text-mined interactions from Literome

Jiang et al., Mol Immunol 2008 : As shown in in vitro studies, while polyinosinic-polycytidylic acid [ poly ( I:C ) ] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not
Dai et al., J Biol Chem 2010 (Enterocolitis, Necrotizing) : In seeking to understand the mechanisms involved, TLR4 dependent HMGB1 signaling increased RhoA activation in enterocytes, increased phosphorylation of focal adhesion kinase, and increased phosphorylation of cofilin, resulting in increased stress fibers and focal adhesions
Li et al., Inflamm Res 2013 (Liver Failure) : Furthermore, the hepatic levels of HMGB1, TLR4 , caspase3 and P65 were also down-regulated by HMGB1 blockade