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HMOX1 — POLDIP2
Text-mined interactions from Literome
Lee et al., Circulation 2004
:
Simvastatin activated p38 and Akt in VSMCs, and the respective inhibitors of
p38 and phosphoinositide 3-kinase (PI3K) greatly
reduced the level of simvastatin induced
HO-1 , which suggests the involvement of p38 and the PI3K-Akt pathway in HO-1 induction
Bundy et al., Antioxid Redox Signal 2005
(Inflammation...) :
Whereas NF-kappaB appears crucial in ICAM-1 induction,
p38 activation itself is not
sufficient to confer
HO-1 expression and may not be involved in HO-1 and ICAM-1 induction in A549 cells
Hsu et al., J Cell Physiol 2008
:
Herein, we show that Curcumin dose dependently
induced HO-1 expression and
HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2,
p38alpha , and PI3-kinase
Churchman et al., J Cell Mol Med 2009
:
TGF-beta(1) failed to induce HO-1 expression in MAoSMC derived from Nrf2-deficient mice, and
HO-1 induction by TGF-beta(1) in HAoSMC was
attenuated by inhibition of extracellular signal regulated kinase or c-jun-N-terminal kinase but not
p38 mitogen activated protein kinase
Huang et al., Toxicol Appl Pharmacol 2012
:
Inhibition of
p38 mitogen activated protein kinase ( MAPK ) but not extracellular signal regulated kinase ( ERK ) significantly
blocked induction of
HO-1 by Vit
Wang et al., J Biochem Mol Toxicol 2013
:
Both proteins were regulated by
p38 , and the feedback regulation of
HO-1 on Cox-2 was
mediated through p38