Gene interactions and pathways from curated databases and text-mining

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HMOX1 — POLDIP2

Text-mined interactions from Literome

Lee et al., Circulation 2004 : Simvastatin activated p38 and Akt in VSMCs, and the respective inhibitors of p38 and phosphoinositide 3-kinase (PI3K) greatly reduced the level of simvastatin induced HO-1 , which suggests the involvement of p38 and the PI3K-Akt pathway in HO-1 induction
Bundy et al., Antioxid Redox Signal 2005 (Inflammation...) : Whereas NF-kappaB appears crucial in ICAM-1 induction, p38 activation itself is not sufficient to confer HO-1 expression and may not be involved in HO-1 and ICAM-1 induction in A549 cells
Hsu et al., J Cell Physiol 2008 : Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha , and PI3-kinase
Churchman et al., J Cell Mol Med 2009 : TGF-beta(1) failed to induce HO-1 expression in MAoSMC derived from Nrf2-deficient mice, and HO-1 induction by TGF-beta(1) in HAoSMC was attenuated by inhibition of extracellular signal regulated kinase or c-jun-N-terminal kinase but not p38 mitogen activated protein kinase
Huang et al., Toxicol Appl Pharmacol 2012 : Inhibition of p38 mitogen activated protein kinase ( MAPK ) but not extracellular signal regulated kinase ( ERK ) significantly blocked induction of HO-1 by Vit
Wang et al., J Biochem Mol Toxicol 2013 : Both proteins were regulated by p38 , and the feedback regulation of HO-1 on Cox-2 was mediated through p38