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HSPB1 — MAPK1
Text-mined interactions from Literome
Hedges et al., J Biol Chem 1999
:
Activation of p38 (
MAPK )
resulted in the phosphorylation of
HSP27 ( heat shock protein 27 ), which may modulate F-actin polymerization ... Inhibition of p38 (
MAPK ) activity
inhibited phosphorylation of
HSP27
Leal et al., Toxicol Appl Pharmacol 2002
:
Lead stimulated
p38MAPK dependent
Hsp27 phosphorylation
Mizutani et al., Biochem Biophys Res Commun 2004
(MAP Kinase Signaling System...) :
The p38
MAPK inhibitor, SB203580,
inhibited effectively phosphorylation of
HSP-27 , CREB, and eIF4E in SARS-CoV infected cells
Marais et al., Basic Res Cardiol 2005
:
The results suggest that p38
MAPK activation
triggers HSP27 phosphorylation during both the preconditioning protocols and during sustained ischaemia
Berkowitz et al., J Biol Chem 2005
(Pemphigus) :
Inhibition of
p38MAPK activity
prevented PV IgG induced
HSP27 phosphorylation, keratin filament retraction, and actin reorganization
Buitrago et al., J Cell Biochem 2006
:
Of relevance, 1alpha,25 ( OH ) 2D3 induced in the C2C12 line the stimulation of
mitogen activated protein kinase activating protein kinase 2 ( MAPKAP-kinase 2 ) and subsequent phosphorylation of
heat shock protein 27 (HSP27) in a p38 kinase activation dependent manner
Rafiee et al., Am J Physiol Cell Physiol 2006
:
The p38
MAPK inhibitor ( SB-203580 ) and p38 MAPK siRNA
blocked Hsp27 and Hsp70 mRNA induction, suggesting a role for MAPKs in the HEMEC heat shock response
Shi et al., Breast Cancer Res Treat 2006
(Breast Neoplasms) :
Inhibition of p38
MAPK resulted in decreased
phospho-HSP-27 and phospho-Akt, while down-regulation of HSP-27 with a small interfering RNA decreased phosphorylation of Akt, directly linking activation of p38 to Akt
Yuan et al., J Cell Biochem 2008
(Carcinoma, Pancreatic Ductal...) :
PKD, PKD2, and p38
MAPK mediate
Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells ... Thus, neurotensin
induces Hsp27 Ser-82 phosphorylation through p38
MAPK- and PKC/PKD dependent pathways in PANC-1 cells
Nomura et al., Biochem Pharmacol 2007
(Glioblastoma) :
SB203580 or p38MAPK siRNA blocked these phenomena, indicating that
Hsp27 phosphorylation and translocation from cytosol to membrane were
mediated by
p38MAPK
Li et al., Am J Physiol Heart Circ Physiol 2008
(Disease Models, Animal...) :
Inhibition of p38
MAPK with SB-203580
blocked the insulin induced phosphorylation of
Hsp27 and the improved functional recovery
Srinivasan et al., Am J Physiol Heart Circ Physiol 2008
:
The parallel activation of
Hsp27 by NE was p38
MAPK dependent and led to its dissociation from actin filaments and translocation from membrane to cytosol and increased actin polymerization ... Both Hsp27 and Hic-5 activation resulted in their association within the same time frame as NE-induced contraction, and the inhibition of either p38
MAPK or Src
inhibited the interaction between
Hsp27 and Hic-5 and the contractile response
Su et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
TNF stimulation induced p38
MAPK dependent phosphorylation of MK2 and
HSP27
Garcia et al., J Biol Chem 2009
:
These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38
MAPK dependent association of
HSP27 and p115RhoGEF
Zoubeidi et al., Cancer Res 2010
(MAP Kinase Signaling System...) :
Because
Hsp27 can be
activated by both
MAPK and Akt pathways, it is possible that interactions between IGF-I signaling and Hsp27 phosphoactivation function to promote castrate-resistant progression
Murai et al., Acta Med Okayama 2010
:
We found that
heatshock activated p38
MAPK at 3 min after exposure to a temperature of 44 degrees C in stress-hypersensitive PC12m3 mutant cells, while it activated JNK at 20 min after the same heat treatment
Jonak et al., J Dermatol Sci 2011
(MAP Kinase Signaling System) :
Inhibition of
p38-MAPK resulted in a downregulation of
hsp27 in KC and SE. Additionally, in the presence of SB203580 Ca ( 2+ ) induced expression of pro-filaggrin and loricrin was inhibited at the protein level and expression of filaggrin, keratin 10, and transglutaminase 1 at the mRNA level
Clements et al., Am J Physiol Heart Circ Physiol 2011
:
p38
MAPK dependent small
HSP27 and aB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest
Kato et al., Endocrinology 2011
:
On the other hand, anisomycin, a p38
MAPK activator,
caused the phosphorylation of
HSP27 in both sphingosine 1-phosphate stimulated untransfected MC3T3-E1 cells and HSP27 transfected MC3T3-E1 cells
Shiryaev et al., Journal of molecular signaling 2011
:
Both stress and cAMP elevating stimuli can cause F-actin remodeling, but whereas the in vivo
role of
p38MAPK-MK2 in stress triggered
HSP27 phosphorylation and actin reorganization is well established, it is not known whether MK2 is involved in cAMP/PKA induced F-actin rearrangements
Nakashima et al., Cancer Lett 2011
(Pancreatic Neoplasms) :
The inhibitions of p38
MAPK and MAPKAPK-2
reduced the phosphorylation of
HSP27 and apoptosis in gemcitabine treated cells
Drastichova et al., PloS one 2012
(Morphine Dependence...) :
Besides that morphine exposure up-regulated
MAPK p38 ( isoform CRA_b ) which is a well-known up-stream mediator of phosphorylation and
activation of
HSP27 and a-B crystallin
Maizels et al., Endocrinology 1998
:
FSH induced phosphorylation of HSP-27 was blocked by pretreatment with the p38 MAPK inhibitor SB 203580, indicating that p38
MAPK activation is
necessary for FSH induced
HSP-27 phosphorylation ... The results of these experiments show that the p38 MAPK pathway is activated in GC in response to FSH in a cAMP/PKA dependent manner, and that p38
MAPK activity is
required for FSH induced
HSP-27 phosphorylation as well as rounding/aggregation in GC