◀ Back to EGFR

EGFR — IFNG

Text-mined interactions from Literome

Uribe et al., Am J Physiol Gastrointest Liver Physiol 2002 : In total, our findings suggest an increase in functional TGF-alpha and activation of the EGFr in response to IFN-gamma
Mascia et al., Am J Pathol 2003 (Dermatitis, Contact...) : During inflammatory skin disorders such as psoriasis, atopic dermatitis, and allergic contact dermatitis, epidermal keratinocytes overexpress large amounts of soluble epidermal growth factor receptor ligands in response to tumor necrosis factor alpha and interferon gamma
Boente et al., Am J Obstet Gynecol 1992 (Ovarian Neoplasms) : The effect of interferon gamma on epidermal growth factor receptor expression in normal and malignant ovarian epithelial cells ... We examined the effect of interferon gamma on proliferation and epidermal growth factor receptor expression in ovarian cancer cell lines and normal ovarian epithelial cells ... Scatchard analysis of anti-epidermal growth factor receptor antibody binding, and Western blotting of immunoprecipitates was used to assess the effect of interferon gamma on epidermal growth factor receptor expression
Ciesielski et al., Cancer Immunol Immunother 2005 (Brain Neoplasms...) : Splenocytes and CD8+ T cells from vaccinated rats produced the Th1 cytokine IFN-gamma in vitro in response to stimulation by rat glioma cells expressing EGFRvIII, but not by those expressing wild-type EGFR
Burova et al., FEBS Lett 2007 : IFNgamma induced EGFR transactivation requires EGFR kinase activity, as well as activity of the Src-family tyrosine kinases and JAK2
Andersen et al., Int J Cancer 2008 : Recently, we reported that epidermal growth factor receptor (EGFR) induce expression of a module of genes known to be inducible by interferons and particularly interferon-gamma
Gonchar et al., Tsitologiia 2008 : It was shown that IFNgamma induced EGFR transactivation is impossible in some cancer epithelial cells ... Here, we hypothesize that IFNgamma dependent EGFR transactivation in these cells correlates with EGFR quantity on the cell surface ... HEK293delta99 cells demonstrated EGFR transactivation in response to IFNgamma unlike the parent HEK293 cells, in which transactivation lacked ... In HEK293delta99 and A431 cells, the time courses of EGFR activation induced by IFNgamma have the same pattern ... In HEK293delta99 cells like A431, IFNgamma induced EGFR transactivation requires EGFR kinase activity and occurs via autophosphorylation mechanism ... Taken together, these data provide direct evidence of the dependence of IFNgamma induced EGFR transactivation upon EGFR expression level in epithelial cells
Burova et al., Tsitologiia 2010 : Recently, we have demonstrated the transactivation of the epidermal growth factor receptor (EGFR) in response to IFNgamma ( Burova et al., 2007 ) and provided direct evidence for the dependence of IFNgamma induced EGFR transactivation upon EGFR expression level in epithelial cells ( Gonchar et al., 2008 )
Bernstein et al., J Biol Regul Homeost Agents 1988 (Carcinoma, Squamous Cell) : Association of interferon-gamma induced growth inhibition and modulation of epidermal growth factor receptor gene expression in squamous cell carcinoma cell lines
Alexandroff et al., Eur J Cancer 1995 (Carcinoma, Transitional Cell...) : IFN gamma reduced EGFR expression on two of eight cell lines ( RT4, SD )
Hobeika et al., Int J Cancer 1998 (Neoplasm Invasiveness...) : For example, IFN gamma , but not IFN alpha, caused a significant reduction in epidermal growth factor receptor expression as well as an increase in the adhesion molecules intercellular adhesion molecule-1 and integrin alpha3