Gene interactions and pathways from curated databases and text-mining

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IFNL1 — IRF3

Text-mined interactions from Literome

Osterlund et al., J Immunol 2007 : To conclude, the data suggest that the IFN-lambda1 gene is regulated by virus activated IRF3 and IRF7, thus resembling that of the IFN-beta gene, whereas IFN-lambda2/3 gene expression is mainly controlled by IRF7, thus resembling those of IFN-alpha genes
Thomson et al., Proc Natl Acad Sci U S A 2009 : We conclude that IFN-lambda1 gene expression requires NF-kappaB, and we propose a model for IFN-lambda1 gene regulation, in which IRF and NF-kappaB activate gene expression independently via spatially separated promoter elements