Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Min et al., Glia 2012 : Finally, we demonstrate that IGF-I mediated G2/M regulation requires mammalian target of rapamycin activity
Miyazaki et al., FEBS J 2010 : The present study aimed to test the hypothesis that IGF-1 activation of mTOR in C2C12 myotubes requires a phosphorylation dependent, altered distribution of the tuberous sclerosis complex (TSC)1/TSC2 complex from the membrane to the cytosol
Patel et al., J Biol Chem 2002 : Insulin regulation of insulin-like growth factor binding protein-1 gene expression is dependent on the mammalian target of rapamycin , but independent of ribosomal S6 kinase activity
Ren et al., Proc Natl Acad Sci U S A 2010 (MAP Kinase Signaling System) : Hypoxia suppresses basal and IGF induced Akt-mTOR and p38 activity, whereas it enhances and prolongs IGF induced Erk1/2 activation in a HIF-1 dependent fashion
Li et al., J Endocrinol 2005 : Western blot analysis indicated that HG and IGF-1 stimulated phosphorylation of Akt and mTOR
Melnik , Hautarzt 2013 (Acne Vulgaris...) : mTORC1 , the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is activated by insulin, IGF-1 and branched-chain essential amino acids, especially leucine ... mTORC1 , the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is activated by insulin, IGF-1 and branched-chain essential amino acids, especially leucine
Tsai et al., J Nutr Biochem 2011 (Neovascularization, Pathologic) : Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1 induced activation of IGF-1R and its downstream signaling targets, including, extracellular signal regulated kinase, Akt, mTOR , p70S6K, 4EBP and cyclin D1
Crowe et al., Mech Ageing Dev 2009 : Experiments using specific kinase inhibitors suggested that activation of proteasome by IGF-I involves phosphatidyl inositol 3-kinase and mammalian target of rapamycin signaling
Cybulski et al., Proc Natl Acad Sci U S A 2009 (Fatty Liver) : mTORC2 , which consists of rictor, mSIN1, mLST8, and mTOR, is activated by insulin/IGF1 and phosphorylates Ser-473 in the hydrophobic motif of Akt/PKB
Dennis et al., J Biol Chem 2013 : These findings were extended to a cell culture system wherein loss of 4E-BP1 and 4E-BP2 resulted in elevated interaction of p70S6K1 with IGF1 induced activation of mTORC1 in conjunction with an enhanced rate of p70S6K1 phosphorylation at Thr-389
Wahdan-Alaswad et al., Cancer Res 2010 (Prostatic Neoplasms) : Immunohistochemical analysis of non-malignant and malignant prostate tissues offered in vivo support for our model that IGF-I mediated activation of mTOR suppresses phosphorylation of the BMP activated Smad transcription factors
Bhatia et al., Cell cycle (Georgetown, Tex.) 2010 (Medulloblastoma) : IGF activates the mammalian Target of Rapamycin (mTOR) , a growth promoting kinase normally kept in check by the tumor suppressive Tuberous Sclerosis Complex (TSC), comprised of TSC1 and TSC2
O' Neill , Exp Gerontol 2013 (Alzheimer Disease) : Therapeutic approaches targeted at normalizing signaling through either the neuronal PI3-kinase/Akt/mTOR pathway or its activation by insulin and IGF-1 have been shown to be protective against the development of AD pathology and cognitive decline in animal models of AD and some of these therapies are entering clinical trials in patients with the disease
Mingo-Sion et al., Breast Cancer Res Treat 2005 (Breast Neoplasms) : PKCdelta and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells
Ham et al., Exp Cell Res 2013 (Cardiomegaly...) : TRIM72 specifically regulated IGF-1 dependent AKT-mTOR signaling , resulting in a reduction of the size of cardiomyocytes
Burgos et al., Domest Anim Endocrinol 2010 : In addition, IGF-1 stimulated mTORC1 kinase activity toward 4E-BP1 in vitro
Roos et al., Am J Physiol Cell Physiol 2009 : We hypothesized that glucose, insulin, and IGF-I regulate placental amino acid transporters by inducing changes in mTOR signaling
Ching et al., Exp Physiol 2013 : Likewise, IGF-1 stimulated phosphorylation of Akt S473, Akt T308, mTOR and S6K was lower in isolated soleus muscles from ATM ( +/- ) mice compared with muscles from ATM ( +/+ ) mice
Sobolewska et al., Eur J Cell Biol 2009 : We also show that IGF-I and EGF are involved in the activation of mTOR in bovine MEC, whereas inhibition of mTOR by rapamycin abrogated the suppressive effects of IGF-I and EGF on autophagy
Chenal et al., Eur J Neurosci 2008 : Investigation of the putative signalling pathways leading to translation activation revealed that insulin and IGF-1 induced p44- and p42 MAPK, Akt and mTOR phosphorylation
Thimmaiah et al., Cancer Res 2010 (Rhabdomyosarcoma) : Results indicate that IGF-I signaling to Bad requires activation of PI3K and PKC ( mu, theta, epsilon ) but not mTOR , Ras-extracellular signal regulated kinase 1/2, protein kinase A, or p90 ( RSK )
Dillon et al., J Clin Endocrinol Metab 2009 : Basal IGF-I protein expression increased in SUP after 3 months ( P = 0.05 ), with no changes in androgen receptor or total and phosphorylated Akt, mammalian target of rapamycin , S6 kinase, and 4E-binding protein