Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Memmott et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Carcinoma...) : This suggested that metformin indirectly inhibited mTOR in lung tissue by decreasing activation of insulin-like growth factor-I receptor/insulin receptor and Akt upstream of mTOR
He et al., Ann Oncol 2012 (Breast Neoplasms...) : Human epidermal growth factor receptor ( HER2 ), insulin receptor and IGF-I receptor involve the same PI3K/AKT/mTOR signaling , and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
O'Neill et al., Biochem Soc Trans 2012 (Alzheimer Disease) : Reducing IIS activity in animal models by decreasing IGF-1R levels or inhibiting mTOR activity alters Aß and tau protein homoeostasis towards less toxic protein conformations, improves cognitive function and extends healthy lifespan
Xie et al., Cancer cell international 2013 : Klotho is a tumor suppressor in gastric cancer, which regulates IGF-1R phosphorylation and the subsequent activation of IRS-1/PI3K/Akt/mTOR signaling , tumor cell proliferation, apoptosis, and autophagy
Qin et al., J Biochem 2011 : mTOR as a main downstream target of AKT is not involved in the AKT mediated down-regulation of IGF1R
Tsai et al., J Nutr Biochem 2011 (Neovascularization, Pathologic) : Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1 induced activation of IGF-1R and its downstream signaling targets, including, extracellular signal regulated kinase, Akt, mTOR , p70S6K, 4EBP and cyclin D1