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IL10 — IL12RB1
Text-mined interactions from Literome
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and
IL-10 secretion
Ong'echa et al., Clin Immunol 2008
(Anemia...) :
Since IL-23 and IL-12 share the IL-12p40 subunit and
IL-12Rbeta1 receptor, and are
down-regulated by
IL-10 , relationships among these cytokines were explored in Kenyan children with varying severities of malarial anemia
Wu et al., Eur J Immunol 1997
:
Anti-CD3 induced expression of
IL-12Rbeta1 and of low-affinity IL-12 binding sites was partially
inhibited by TGF-beta2,
IL-10 and IL-4 ; however, TGF-beta2 and IL-10 completely abolished anti-CD3 induced expression of high-affinity IL-12 binding sites ... These results suggest that Th2 cell derived cytokines can inhibit IL-12 induced biological functions by inhibiting IL-12R expression and that expression of a second subunit of the
IL-12R ( IL-12Rbeta2 ), required for the formation of high-affinity IL-12 binding sites, may be more highly
regulated by TGF-beta2 and
IL-10 than is expression of IL-12Rbeta1
Zhang et al., J Immunol 1999
(Tuberculosis) :
In M. tuberculosis stimulated peripheral blood T cells from healthy tuberculin reactors, recombinant
IL-10 and TGF-beta
reduced IL-12R beta 1 and IL-12R beta 2 expression, as well as IFN-gamma production