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BTK — IL12B

Text-mined interactions from Literome

Hasan et al., Immunology 2008 : In this study we set out to investigate the potential role of Btk in Toll-like receptor 9 (TLR9) activation and the production of pro-inflammatory cytokines such as interleukin (IL)-6, tumour necrosis factor (TNF)-alpha and IL-12p40
Lee et al., J Biol Chem 2008 : The addition of exogenous recombinant IL-10 could suppress IL-12 production by TLR9 activated Btk ( -/- ) B cells, suggesting that in B cells, Btk negatively regulates IL-12 through the induction of autocrine IL-10 production ... Thus, Btk plays an important role in TLR9 signaling and acts separately to regulate NFkappaB RelA activation as well as IL-10 and IL-12 production in B cells