Gene interactions and pathways from curated databases and text-mining

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CD4 — IL16

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Mashikian et al., J Immunol 1999 : Reciprocal desensitization of CCR5 and CD4 is mediated by IL-16 and macrophage-inflammatory protein-1 beta, respectively
Mathy et al., J Immunol 2000 : Cutting edge : CD4 is not required for the functional activity of IL-16
Kitchen et al., Blood 2002 : IL-16 mediated ligation of CD4 expressed on CD8 T cells was found to induce an intracellular signal that directs migration of these cells in vitro
Pepe et al., Curr Pharm Des 2006 : This Th1 polarizing activity is mediated by interleukin-12 released by infected CDs in the presence of CD4 ( + ) cells
Ariga et al., Immunology 2007 : Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive CD4 ( + ) T cells induces transient T-bet expression, interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Liu et al., Cytokine 2007 : IL-16 signaling specifically induces STAT6 activation through CD4 ... To gain a better understanding of how the biologic activities of IL-16 are regulated following receptor engagement ( CD4 ) we have analyzed the activation state of numerous STAT proteins in primary human peripheral blood mononuclear cells ( PBMCs ) and the human monocytic cell line THP-1 following IL-16 stimulation
Yadav et al., J Immunotoxicol 2010 : As IL-16 ( at locally high levels ) can induce CD4 ( + ) cell death via apoptosis, this potential outcome among the A549 cells was also evaluated using TUNEL and changes in expression of caspase-3 and the pro-apoptotic and anti-apoptotic proteins of Bcl-2 family
Fenster et al., Neurosci Lett 2010 : The role of CD4 dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons
Vandergeeten et al., Blood 2013 (HIV Infections) : When administered to HIV infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4 ( + ) T cells by promoting their survival and proliferation
Cruikshank et al., J Immunol 1996 : In addition, IL-16 had no effect on surface expression of CD3 or CD4
Center et al., Int J Biochem Cell Biol 1997 (Asthma) : IL-16 requires the expression of CD4 for its functions, which include induction of chemotaxis, interleukin-2 receptor and HLA-DR expression, reversible inhibition of TcR/CD3 dependent activation and induction of a repressor of HIV-1 transcription
Parada et al., J Immunol 1998 : IL-16 , in a CD4 dependent manner, induces high affinity IL-2R ( CD25 ) selectively on CD4+ T cells ... IL-16 increased CD4+ T cell IL-2Ralpha and beta expression, but had no effect on expression of IL-2Rgamma
Suzuki et al., J Virol 1999 : Among them, interleukin-12 (IL-12) and IL-4 induce naive CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively