◀ Back to PI3

IL2 — PI3

Text-mined interactions from Literome

Sauvonnet et al., Mol Microbiol 2002 : Consistent with the observation that YopH inactivated the Akt pathway, YopH inhibited PI 3-kinase dependent secretion of interleukin 2 and proliferation
Remillard et al., J Biol Chem 1991 (Second Messenger Systems) : IL-2 triggered a direct association of PI 3-kinase with the IL-2 receptor as detected in immunoprecipitates using anti-IL-2 receptor beta chain antibody
Truitt et al., J Biol Chem 1994 : Interleukin-2 (IL-2) signaling results in tyrosine phosphorylation of the 75-kDa IL-2 receptor (IL-2R) beta chain and the activation of phosphatidylinositol 3'-kinase (PI3-K)
Karnitz et al., J Exp Med 1994 : Previous studies have described a physical association between Fyn and a potential downstream substrate, phosphatidylinositol 3-kinase ( PI3-kinase ) as well as the IL-2 dependent activation of PI3-kinase in T cells ; however, the role of Fyn in IL-2 induced PI3-kinase activation remains unclear
Rebollo et al., Cytokine 1995 : Rap inhibits IL-2 stimulated phosphatidylinositol 3 (PI3) kinase activity in TS1 alpha beta cells
Ueda et al., Int Immunol 1995 : Another inhibitor of PI 3-kinase , LY294002, also resulted in augmentation of anti-CD28 induced IL-2 secretion by Jurkat cells
Kanazawa et al., Cell Immunol 1994 : IL-2 binding also induces activation of PI 3-kinase ... PI 3-kinase products also increased in response to IL-2 in these cells ... Activation of PI 3-kinase in response to IL-2 was not abolished by treatment of cells with rapamicin and occurred only in cells which express mitogenically competent receptors ... The results presented in this study suggest that IL-2 mediated PI 3-kinase activation occurs by a mechanism distinct from interaction with the lck protein-tyrosine kinase
Susa et al., Biochem Biophys Res Commun 1996 : Two T cell-specific src-family tyrosine kinases, p56 lck ( lck ) and p59 fyn ( fyn ), are implicated in regulating PI 3-kinase activity in response to interleukin-2 (IL-2) , a cytokine that induces T cell proliferation ... In order to understand the mode of PI 3-kinase activation by the IL-2 receptor, we examined the association of PI 3-kinase to SH2 and SH3 domains of lck and fyn in IL-2 dependent kit 225 cells
Ahmed et al., Proc Natl Acad Sci U S A 1997 : The activation of Akt by IL-2 via the PI3-kinase and the rescue of the PI3-kinase mediated antiapoptotic and proliferative IL-2 signals by catalytically active Akt indicate that these signals are transduced by Akt
Reif et al., J Biol Chem 1997 : Phosphatidylinositol 3-kinase ( PI 3-kinase ) is activated by the cytokine interleukin-2 (IL-2)
Brennan et al., Immunity 1997 : Phosphatidyl inositol 3-kinase (PI3K) is activated by IL-2
Eder et al., J Biol Chem 1998 : Here, we show that for normal mouse lymph node T cells, PI 3-kinase activity is required for interleukin-2 (IL-2) production following TCR mediated activation
Gadina et al., J Immunol 1999 : Recently, it has been shown that the SH2 containing phosphatase, SHP-2, becomes phosphorylated in response to IL-2 stimulation, associates with PI3'-kinase and Grb2, and can exert a positive regulatory role in IL-2 signaling