Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Narita et al., Science 2011 : mTOR recruitment to the TASCC was amino acid- and Rag guanosine triphosphatase dependent, and disruption of mTOR localization to the TASCC suppressed interleukin-6/8 synthesis
Ohtani et al., Blood 2008 (Leishmaniasis, Cutaneous) : Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide induced interleukin-12 production in dendritic cells
Song et al., J Pharmacol Exp Ther 2011 : Conversely, down-regulation of DDIT4 with small interfering RNA dampened the capacity of PDTC to block IL-6 dependent mTOR activation
Schreml et al., Int Immunopharmacol 2007 : mTOR-inhibitors simultaneously inhibit proliferation and basal IL-6 synthesis of human coronary artery endothelial cells ... mTOR-inhibitors failed to suppress basal/TNF induced secretion of IL-8 and MCP-1, but IL-6 synthesis after TNF-induction was reduced to 35 % ... In contrast to human saphenous vein ECs ( HSVECs ), mTOR-inhibitors also reduced basal IL-6-secretion of HCAECs ( to 55 % ) and cell proliferation was simultaneously inhibited within the same concentration range
White et al., Am J Physiol Endocrinol Metab 2013 (Cachexia...) : How IL-6 can induce suppression of mTORC1 signaling remains to be established ... The purpose of this study was to examine mTOR complex 1 (mTORC1) activation and regulation by IL-6 during cancer cachexia ... IL-6 effects on mTOR activation were examined in Apc ( Min/+ ) mouse skeletal muscle and C2C12 myotubes
Song et al., Am J Physiol Cell Physiol 2010 (Cardiomegaly...) : mTOR overexpression suppressed LPS induced secretion of IL-6 ( P < 0.001 ), and the mTOR inhibitors rapamycin and PP242 abolished this inhibitory effect of mTOR
Kim et al., J Biol Chem 2008 (Carcinoma, Hepatocellular...) : Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling