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IL6 — IRF5

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: IRF5 → IL6 (protein-protein, expression)

Text-mined interactions from Literome

Mudter et al., Inflamm Bowel Dis 2011 (Colitis...) : In contrast to DSS colitis, IRF4 deficiency was protective in T-cell dependent transfer colitis associated with reduced RORa/?t levels and impaired IL-6 , IL-17a, and IL-22 production, suggesting that IRF4 acts as a master regulator of mucosal Th17 cell differentiation
Yasuda et al., Int Immunol 2013 : IRF5 deficiency reduces IFN-a, IFN-ß and IL-6 production by Toll-like receptor 9 (TLR9)- and TLR7 stimulated DCs and reduces TLR7- and TLR9 induced IL-6 production by B cells to a similar extent in the two lines
Harroch et al., J Biol Chem 1993 : The dissociation between induction of mRNAs and of protein binding observed suggests that the activity of the IRF proteins is regulated by IL-6