Gene interactions and pathways from curated databases and text-mining

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CASP14 — IRF6

Text-mined interactions from Literome

Watson et al., FEBS Lett 1999 : LPS , GM-CSF and increased glutathione stabilised the mitochondria and inhibited caspase 3
Tsutsui et al., Immunol Rev 2000 (Disease Models, Animal...) : LPS induces IL-18 secretion from Kupffer cells in a caspase-1 dependent manner
Oberholzer et al., Shock 2000 (Sepsis) : Inhibition of caspase activity by Z-VAD significantly reduced lipopolysaccharide (LPS) and Staphylococcus aureus ( SAC ) induced release of mature IL-1beta in septic patients and controls
So et al., Immunol Invest 2000 : Consistently, LPS markedly increases the catalytic activity of caspase 3-like protease but not caspase 1-like protease in IFN-gamma treated cells
Chakravortty et al., Infect Immun 2001 : The overexpression of the dominant negative mutant of JNK/SAPK and the addition of a JNK/SAPK inhibitor blocked iNOS expression but did not block LPS induced caspase 3 activation
Fantuzzi et al., Eur J Immunol 2001 : In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP
Suk et al., Immunol Lett 2001 : IFNgamma increased lipopolysaccharide (LPS) induced IL-18 production and caspase-1 expression, while PGE ( 2 ) inhibited LPS induced IL-18 production
Perlman et al., Eur J Immunol 2001 : Here, we demonstrate that LPS and TNF-alpha up-regulate Flip and suppress spontaneous Fas-FasL mediated monocyte apoptosis and caspase 8 and 3 activation
Hur et al., FEBS Lett 2001 (MAP Kinase Signaling System) : However, SB203580 ( specific inhibitor of p38 kinase ), but not PD98059 ( specific inhibitor of ERK kinase ), inhibited LPS induction of caspase-11 , indicating that induction of caspase-11 by LPS in astrocytes was mediated through the p38 MAPK pathway
Liu et al., J Pharmacol Exp Ther 2002 (Drug-Induced Liver Injury) : Gel shift assay and Western blot analysis supported microarray results, showing that V-PYRRO/NO suppressed GlaN/LPS induced activation of nuclear factor-kappaB and GlaN/LPS induced increases in caspase-1 , caspase-8, tumor necrosis factor receptor 1 (TNFR1) associated death domain, and TNF related apoptosis inducing ligand ... Immunohistochemical analysis further revealed that GlaN/LPS induced activation of TNFR1, caspase-3 , and hepatocellular apoptosis was ameliorated by V-PYRRO/NO treatment
Harstad et al., Toxicol Appl Pharmacol 2002 (Drug-Induced Liver Injury...) : LPS/Gln-treatment caused a 7.8-fold increase in caspase-3 activity in WT mice but did not increase caspase-3 in TNF-KO mice
Hull et al., J Immunol 2002 : LPS induced loss of mitochondrial transmembrane potential, cytochrome c release, and caspase activation are all blocked by TRAF6-C
Schauvliege et al., J Biol Chem 2002 : Transient transfections with caspase-11 promoter-luciferase reporter constructs and deletion/mutation analysis revealed an essential role for NF-kappaB binding in the up-regulation of caspase-11 in response to LPS
Kang et al., Cell Death Differ 2002 (Disease Models, Animal...) : Here we report that LPS induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7
Slomiany et al., Biochem Biophys Res Commun 2002 (MAP Kinase Signaling System) : Introduction of NOS-2 inhibitor, L-NAME, not only countered the LPS induced increase in NO generation, caspase-3 activity and apoptosis, but caused the impedance of the LPS inhibition on mucin synthesis
Carracedo et al., Nephrol Dial Transplant 2002 : They additionally suggest that LPS regulates the proteolytic activation of caspase-3
Suk et al., J Pharmacol Exp Ther 2003 : Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting caspase-11 activation, interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation
Ahn et al., Int J Mol Med 2003 : Among the anti-apoptotic genes activated by NF-kappaB, transcripts for inhibitor of apoptosis proteins ( IAPs ) are rapidly induced in response to LPS and delay apoptosis through direct and indirect inhibition of caspase activity
Fukui et al., J Immunol 2003 : LPS stimulation induced the expression of Fas, caspase 8, cellular FLIP Bfl-1/A1, and Bcl-x, but not FasL, TNFR p55, Bak, Bax, and Bad at the transcriptional level
Alikhani et al., J Biol Chem 2003 : Fluorometric studies demonstrated that LPS in vivo significantly increased caspase-8 and caspase-3 activity and by use of specific inhibitors, the activation of caspase-3 was shown to be initiated by caspase-8 with no contribution from caspase-9
Li et al., J Org Chem 2003 : The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS induced caspase-11 expression, using a convergent synthetic approach, is described
Slomiany et al., Biochem Biophys Res Commun 2003 (Bacteroidaceae Infections) : The impedance by leptin of the LPS inhibitory effect on mucin synthesis was blocked by wortmannin, an inhibitor of PI3K, which also obviated the inhibitory effect of leptin on the LPS induced upregulation in apoptosis, caspase-3 activity, and NO generation ... A potentiation in the impedance by leptin of the LPS induced apoptosis, caspase-3 activity, and NO generation was, however, attained with NOS-2 inhibitor, 1400W, that also caused further enhancement in the impedance by leptin of the LPS detrimental effect on mucin synthesis
Nolan et al., Exp Neurol 2003 : Furthermore, administration of the p38 inhibitor, SB203580, abolished the LPS induced increase in caspase-3 activation
Slomiany et al., IUBMB Life 2004 : Moreover, the inhibitory effect of ciglitazone on the LPS induced reduction in mucin synthesis and upregulation in apoptosis, caspase-3 activity, and NO generation was blunted by a selective inhibitor of tyrosine kinase Src, PP2, responsible for ligand independent EGFR transactivation
Elssner et al., J Immunol 2004 : In contrast, stimulation with bacterial LPS inhibited caspase-3 activation and significantly inhibited the release of IL-16
Kuwabara et al., Apoptosis 2004 : These results suggest that LPS does not require caspase activation to induce mitochondrial dysfunction and that mitochondria play a crucial role in the regulation of LPS mediated apoptosis in U937IFN cells
Slomiany et al., Inflammopharmacology 2004 : Moreover, the inhibitory effect of ciglitazone on the LPS induced reduction in mucin synthesis and upregulation in apoptosis, caspase-3 activity and NO generation was countered by PP2, a selective inhibitor of tyrosine kinase Src responsible for ligand independent EGFR transactivation
Alikhani et al., J Dent Res 2004 : Fluorometric studies demonstrated that LPS in vivo significantly increased caspase-8 and caspase-3 activity, which was also dependent on TNF receptor signaling
Arai et al., J Biol Chem 2004 : Our results indicate that the neurotoxic effects of LPS on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and caspase-11 expression in mice
Mica et al., J Am Coll Surg 2004 (Sepsis) : LPS significantly ( p < 0.05 ) reduced spontaneous ( 66.1 +/- 2.3 % to 24.8 +/- 4.8 % ) and CD95 induced ( 90.8 +/- 0.9 % to 64.3 +/- 4.2 % ) apoptosis and caspase-3 activation ... Inhibition of the proteasome completely abolished the antiapoptotic effect of LPS on spontaneous ( 52.6 +/- 2.4 % ) and CD95 induced ( 88.7 +/- 2.6 % ) apoptosis and degradation of caspase-3
Basak et al., J Biol Chem 2005 (MAP Kinase Signaling System) : LPS induced caspase-1 activation was abrogated in cells transfected with caspase-1 ( S376A )
Guo et al., J Am Soc Nephrol 2004 (Acute Kidney Injury...) : LPS induced a significant increase in caspase-3 activity in vehicle treated mice, which was significantly inhibited by z-VAD
Kim et al., Mol Cell Biol 2005 : Here, we demonstrate that LPS induced early caspase activation is essential for macrophage survival because blocking caspase activation with a pancaspase inhibitor ( zVAD [ benzyloxycarbonyl-Val-Ala-Asp ] ) rapidly induced death of activated macrophages
Masaki et al., FASEB J 2005 (Necrosis) : Histamine inhibited the GalN/LPS induced caspase-3 activity in the liver
Endo et al., J Immunol 2006 (Inflammation) : The induction of caspase-11 by LPS was suppressed in Chop knockout mice
Pladzyk et al., Invest Ophthalmol Vis Sci 2006 : Inhibition of AR by two structurally unrelated inhibitors, sorbinil and tolrestat, or ablation by AR siRNA prevented the LPS induced apoptosis, activation of caspase-3 and cleavage of PARP protein
Niu et al., J Mol Cell Cardiol 2008 (Sepsis) : LPS induced increase in caspase-3/7 activity and apoptotic cell death were suppressed in sFas mice compared with WT mice
Lakshmanan et al., J Immunol 2007 : LPS stimulation led to the interaction of endogenous caspase-4 and TNFR associated factor 6 (TRAF6) via a TRAF6 binding motif ( PPESGE ), which we identified in caspase-4
Li et al., Cardiovasc Res 2009 (Disease Models, Animal...) : Lipopolysaccharide (LPS) induces cardiomyocyte caspase-3 activation and proinflammatory factors, in particular tumour necrosis factor-alpha (TNF-alpha) production, both of which contribute to myocardial dysfunction during sepsis ... In cultured adult rat cardiomyocytes, LPS ( 1 microg/mL ) induced calpain and caspase-3 activity, and up-regulated TNF-alpha expression
Imamura et al., J Hepatol 2009 (Granuloma...) : Here we investigated the roles of MyD88 and TRIF in P. acnes induced hepatic granuloma formation and LPS induced caspase-1 activation for IL-18 release ... Subsequent LPS TRIF-dependently activated caspase-1 via Nalp3 inflammasome and induced IL-18 release, eventually leading to the liver injury
Shioiri et al., Biochim Biophys Acta 2009 : Here we show that caspase-3 activation, a biological indicator of apoptosis, is observed in response to lipopolysaccharide (LPS) stimulation even under the influence of endogenous apoptosis inhibitors, and that activated caspase-3 is rapidly released from human umbilical vein endothelial cells ( HUVEC ) ... On the other hand, even in the absence of CHX, a significant increase in caspase-3/7 activity and a cleaved caspase-3 fragment with a slight increase in LDH release was observed in culture supernatants in response to LPS ... These results indicate that caspase-3 is activated by LPS under physiological conditions and suggest that HUVEC escape from cell death by rapidly releasing activated caspase-3 into extracellular space ... In the presence of cycloheximide ( CHX ), an increase in intracellular caspase-3/7 activity in response to LPS was not detected in HUVEC up to 24 h following stimulation even in the presence of LPS binding protein (LBP), soluble CD14 and soluble MD-2, whereas the decrease in cell viability and increase in release of the cellular enzyme lactate dehydrogenase ( LDH ) were observed in a soluble CD14/LBP dependent manner
Xuan et al., Cell Physiol Biochem 2010 : Moreover, LPS decreased and thymoquinone increased caspase 3 and caspase 8 activation and annexin V binding
Slomiany et al., Inflammopharmacology 2010 : The loss in countering effect of ghrelin on the LPS induced changes in apoptosis and caspase-3 activity was attained with Src kinase inhibitor, PP2, as well as Akt inhibitor, SH-5, and cNOS inhibitor, L-NAME, but not the iNOS inhibitor, 1400W
Franchi et al., J Innate Immun 2009 (Inflammation) : Calcium independent phospholipase A2 ( iPLA2 ) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS) ... Bromoenol lactone ( BEL ), an inhibitor that was originally used to support a role for iPLA2 in the secretion of IL-1 beta, prevented caspase-1 activation induced by LPS and ATP as described, and also activation triggered by Salmonella infection and cytosolic flagellin, which rely on the Nlrc4 inflammasome
Zarifkar et al., Eur J Pharmacol 2010 (Memory Disorders) : Also western blot studies revealed that LPS induces hippocampal caspase-3 activation while agmatine treatment prevented it
Slomiany et al., Mediators Inflamm 2010 : The loss in countering effect of ghrelin on the LPS induced changes in apoptosis and caspase-3 activity was attained with Src kinase inhibitor, PP2, as well as Akt inhibitor, SH-5, and cNOS inhibitor, L-NAME
Olin et al., J Neuroimmune Pharmacol 2010 : In vivo morphine treatment synergistically increases LPS induced caspase activity in immune organs ... However, morphine significantly enhanced the LPS induced caspase activity in spleen, thymus, and bone marrow derived immune cells
Sharifi et al., Toxicol Mech Methods 2010 : In western blotting analysis, LPS ( 200 microg/ml ) also enhanced expression of pro-apoptotic Bax and pro-caspase-3 proteins compared to controls, while the expression of Bcl-2 protein was not changed significantly ... From the present results, it might be concluded that LPS can cause PC12 cell death, in which apoptosis plays an important role, possibly by the mitochondrial pathway through higher expression of the Bax as well as caspase 3 protein
Lian et al., Chem Biol Interact 2010 (Liver Failure) : d-GalN/LPS induced caspase-8 and -9 activation was significantly suppressed by gentiopicroside
Jeong et al., Journal of neuroinflammation 2010 (Cerebral Infarction...) : In addition, CYT and quercetin inhibited LPS induced IL-32 expression and caspase-1 activation
Rebola et al., J Neurochem 2011 : The LPS induced increases in phosphorylation of c-jun N-terminal kinase and p38 and activation of caspase 3 were also prevented by SCH58261
Khodagholi et al., Mol Cell Biochem 2011 (Calcium Signaling) : It also inhibited LPS induced cyclooxygenase 2 (COX-2), TNF-a, nuclear factor KappaB (NF-kB), and caspase-3 expression in a dose dependent manner while stabilizing nuclear factor-erythroid 2 p45 related factor 2
Marcuzzi et al., Apoptosis 2011 (Inflammation...) : ALD + LPS induced caspase-3 activation
Bian et al., Invest Ophthalmol Vis Sci 2011 : Meanwhile, caspase-1 expression and protein activation were induced by LPS
Rostami et al., J Mol Neurosci 2012 (Brain Ischemia...) : LPS significantly increased the nuclear NF-?B and expression of COX-2, IL-1ß, and TNF-a, augmented the activity of caspase-3 and PARP cleavage, and in parallel shortened the latencies to enter the dark compartment
Aggarwal et al., Frontiers in physiology 2012 : Finally, our studies showed that LPS induced an increase in the mitochondrial translocation of Bax, caspase 3 activation, and nuclear DNA fragmentation and these parameters were all prevented with GSH-EE
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : We also evaluated the lipopolysaccharide (LPS)- , IL-1a-, and tumor necrosis factor a (TNFa) induced activity of matrix metalloproteinase 3 (MMP-3), MMP-9, and MMP-13 in NLRP3-knockout mice and wild-type mice and the inhibition of caspase 1 with Z-YVAD-FMK and the blockade of IL-1ß with IL-1 receptor antagonist (IL-1Ra)
Wu et al., Int J Immunopathol Pharmacol 2012 (Liver Failure, Acute) : In addition, pretreatment mice with PD dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha) production, myeloperoxidase (MPO) activity, intercellular adhesion molecule-1 ( ICAM-1 ) and endothelial cell adhesion molecule-1 ( ECAM-1 ) expression, caspase-3 activation, and transcription factor nuclear factor-kappa B(NF-kB) activity induced by LPS
Mao et al., Cell Res 2013 (Shock, Septic) : Depletion of iNOS resulted in increased accumulation of dysfunctional mitochondria in response to LPS and ATP, which was responsible for the increased IL-1ß production and caspase-1 activation
Yan et al., Hepatobiliary Pancreat Dis Int 2013 (Liver Failure, Acute) : LPS/D-GalN induced caspase-3 and caspase-9 activation was remarkably suppressed by CA-074me
Wang et al., Apoptosis 2013 (Liver Cirrhosis) : Apoptosis was induced with GCDC, LPS , and alcohol in precision-cut liver slices or bile duct ligation ( BDL ) in rats, as reflected by caspase-3 activity, TUNEL assay, and apoptosis related gene profiles
Teng et al., Mol Med Report 2013 : Our data showed that LPS induced the activation of nuclear factor-?B ( NF-?B ) and its upstream protein caspase 3, upregulated the expression of an additional apoptosis-inducing factor, heat shock protein 60 (HSP60), in BV2 microglial cells and increased the release of TNF-a and HSP60 in the culture media
Tsolmongyn et al., Cell Immunol 2013 : LPS inhibited the activation of caspase 3 and poly ( ADP-ribose ) polymerase and prevented VPA induced apoptosis
Schumann et al., Blood 1998 : We show that LPS induces moderate caspase-1 activity in the monocytic cell line THP-1, in freshly isolated peripheral blood monocytes, and in human umbilical vein endothelial cells ( HUVECs ) in a time- and dose dependent fashion ... LPS induced caspase-1 activation appeared not to result from modulation of caspase-1 transcript accumulation and inhibition of caspase-1 activity was accomplished by two specific inhibitors, YVAD-CHO and YVAD-CMK, capable of alleviating the release of mature IL-1 beta ... Taken together, these results show that LPS moderately activates caspase-1 and that caspase-1 activation contributes to LPS induction of IL-1 beta secretion