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IL9 — IRS2

Text-mined interactions from Literome

Demoulin et al., FEBS Lett 2000 : We show that IL-9 induces IRS2 phosphorylation and association with phosphatidylinositol-3 kinase (PI 3-K) p85 subunit in TS1 cells and BaF/9R cells, which proliferate upon IL-9 stimulation
Zhu et al., J Biol Chem 1997 : However, substitution of the Pro-X-Pro in the BOX1 motif with Ala-X-Ala failed to abolish IL-9 induced cell proliferation but decreased IL-9 mediated tyrosine phosphorylation of JAK kinases, insulin receptor substrate-2 , and signal transducer and activator of transcription 3 ( STAT3 ) and expression of c-myc and junB ... Deletion of this region significantly impaired IL-9 induced cell growth, activation of JAK kinases, insulin receptor substrate-2 , and STAT3 and expression of early response genes