UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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IRS2 — LCK

Pathways - manually collected, often from reviews:

NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IRS1-2 (IRS2/IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IRS1-2 (IRS2/IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction