Gene interactions and pathways from curated databases and text-mining

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ITGAM — TNF

Text-mined interactions from Literome

Kragsbjerg et al., APMIS 2000 : The effects of human recombinant tumour necrosis factor-alpha (TNF-alpha) on neutrophil ( PMNL ) oxidative burst and on CD11b/CD18 and CD14 expression after stimulation with pathogenic or nonpathogenic Neisseria meningitidis were studied using chemiluminescence and flow cytometry ... TNF-alpha caused a significant increase in PMNL CD 11b/CD18 expression after 30 min of incubation at 37 degrees C. TNF-alpha added simultaneously with the bacteria induced a significant increase in PMNL CD11b/CD18 in both strains
Drost et al., Eur J Immunol 2002 : TNF-alpha in contrast caused a small decrease in cell deformability only after 30 min, and shedding of L-selectin, but no change in CD11b levels
Chernyshov et al., FiziolohichnyÄ­ zhurnal (Kiev, Ukraine : 1994) 2002 : Progesterone inhibited TNF stimulated CD54 and CD11b expression on the granulocytes and CD69 expression on lymphocytes by reducing partly the density of these molecules on the surface of cells, and in such way it partly blocked the proinflammatory activity of this cytokine
Diez-Fraile et al., Can J Vet Res 2004 (Mastitis, Bovine) : In addition, we evaluated the effect of lipopolysaccharide (LPS) and tumor necrosis factor (TNF)-alpha on CD11b surface expression in PMN at different stages of lactation in a whole blood model
Montecucco et al., Cell Signal 2008 (Inflammation) : Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 ( Mac-1 ) up-regulation and migration to the CC chemokine CCL3 ( MIP-1alpha ) on human neutrophils through defined signalling pathways ... TNF-alpha induced migration was a consequence of the TNF-alpha induced up-regulation of integrin CD11b/CD18 ( Mac-1 ) on neutrophil surface
Yu et al., Int J Hematol 2008 (MAP Kinase Signaling System) : TNF-alpha enhanced CD11b expression and percent of cell population in the G1 phase induced by DMSO, which are hallmarks for HL-60 cell differentiation
Montecucco et al., J Mol Cell Cardiol 2009 (Disease Models, Animal...) : Furthermore, JWH-133 inhibited the TNF-alpha induced chemotaxis and integrin CD18/CD11b ( Mac-1 ) upregulation on human neutrophils
Rea et al., Age (Dordrecht, Netherlands) 2013 (Disease Progression...) : In 38 subjects ( mean age 85 years ), consecutively enrolled from Belfast Elderly Longitudinal Free Living Aging Study ( BELFAST ), baseline and TNF-a stimulated CD11b/CD18 expression on separated monocytes and neutrophils increased with systolic blood pressure > 120 mmHg ( p?=?0.05 ) and for lymphocytes, with diastolic blood pressure > 80 mmHg ( p? < ?0.05 ) .These findings show increased potential stickiness of intravascular cells with increasing blood pressure which is accentuated by TNF-a, and suggest mechanistic reasons why better hypertension control is important
Matsubara et al., PloS one 2012 : The combination of TNF-a, TGF-ß, and M-CSF induced Kat1 ( + ) CD11b ( + ) cells, but these cells were also induced by TNF-a alone
Silveira et al., Inflamm Res 2013 : Neutrophil surface expression of the Mac-1 integrin subunit, CD11b , was augmented by TNF-a , and this increased expression was also inhibited by simvastatin
Arita et al., Invest Ophthalmol Vis Sci 2013 (Diabetic Angiopathies...) : TNF-a induced ICAM-1 expression, eNOS dephosphorylation, cytoskeletal changes, and CD11b/18 expression in neutrophils were significantly suppressed by fasudil as well as ROCK-specific siRNA
Elbim et al., Eur Cytokine Netw 1995 : PTX reduced CD11b upregulation induced by TNF
Steadman et al., Int J Biochem Cell Biol 1996 : The cell permeable diacyl glycerol, 1,2-dioctanoyl-glycerol ( DiC8 ) and TNF alpha each increased CD11b/CD18 expression on PMN [ maximal at 10-9 M TNF alpha or 10-8 M DiC8 ]
Kuo et al., Tuber Lung Dis 1996 (Tuberculosis, Pulmonary) : Stimulation of AM with TNF-alpha increased H2O2 production and CD11b/CD18 expression
García-Vicuña et al., Arthritis Rheum 1997 : Pretreatment of neutrophils with either NSAID prevented the changes in L-selectin and CD11b expression induced by TNF alpha , GM-CSF, and FMLP, but not those induced by PMA or A23187
Knowles et al., Am J Physiol 1997 (Anoxia) : During reoxygenation, both whole blood PMN phagocytosis and bactericidal activity were reduced in the presence of IL-8, TNF-alpha , or IL-1beta, and in subsets of PMN with reduced phagocytosis H/R reduced CD64, CD32w, CD16, CD35, and CD11b/CD18 expression in the presence of each cytokine
Takeshita et al., Infect Immun 1998 : Furthermore, Northern blot analyses showed that the fimbria induced expression of IL-1beta and TNF-alpha genes in the cells was inhibited strongly by CD18 antibody treatment and slightly by CD11a, CD11b , or CD11c antibody treatment
Katano et al., Anticancer Res 1998 (Pleural Effusion, Malignant) : Tumor necrosis factor alpha (TNF-alpha) induced CD11b/CD18 expression on leukocytes and interferon-gamma (IFN-gamma) induced ICAM-1 expression on tumor cells may play an important role in leukocyte mediated tumor destruction