◀ Back to IL4
IL4 — JAK3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
JAK3
→
IL4
(increases)
Doucet et al., Oncogene 2000*
Evidence: IL-4 and IL-13 also induced the tyrosine phosphorylation of JAK2 in both cell types (Figure 2e,f, upper blots) whereas JAK3 phosphorylation was detected only in lung myo®bro- blasts (Figure 2g,h, upper blots).
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
SHC (SHC1)
(modification, activates)
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BioCarta il 4 signaling pathway:
IRS1/2/GRB2 complex (GRB2)
→
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IRS1/2/GRB2 complex (GRB2)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
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BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
GRB2
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
→
GRB2
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-4 (IL4)
→
IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R)
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-4 (IL4)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, inhibits)
Kashiwada et al., J Immunol 2001, Hanson et al., J Biol Chem 2003, Chen et al., J Immunol 2004, Pernis et al., Proc Natl Acad Sci U S A 1995, Quelle et al., Mol Cell Biol 1995, Hou et al., Science 1994, Shimoda et al., Nature 1996, Haque et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
BCL6 (BCL6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
(T-helper 2 cell differentiation, inhibits)
Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
STAT6 (dimer) complex (STAT6)
(T-helper 2 cell differentiation, activates)
Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL4-mediated signaling events:
ETS1 (ETS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Travagli et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
STAT6 (dimer) complex (STAT6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Travagli et al., J Biol Chem 2004
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SHP1 (PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SHP1 (PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Jiang et al., J Immunol 2001, Wurster et al., Mol Cell Biol 2002, Sun et al., Nature 1995, Izuhara et al., Blood 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IRS1 (IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IRS1 (IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
(modification, collaborate)
Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
IRS2 (IRS2)
(modification, collaborate)
Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2)
→
IRS2 (IRS2)
(modification, collaborate)
Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL2R gamma/JAK3 complex (IL2RG-JAK3)
(modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SOCS5 (SOCS5)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, inhibits)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL2R gamma/JAK3 complex (IL2RG-JAK3)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2)
→
Dok-R (DOK2)
(modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
Dok-R (DOK2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
STAT6 (dimer) complex (STAT6)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Sherman et al., J Immunol 1999
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL2R gamma/JAK3 complex (IL2RG-JAK3)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SOCS1 (SOCS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, inhibits)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL2R gamma/JAK3 complex (IL2RG-JAK3)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
STAT5 (STAT5A/STAT5B)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Mora et al., J Immunol 2001
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
FES (FES)
(modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
FES (FES)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
CD40LG (CD40LG)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(transcription, activates)
Gupta et al., J Exp Med 1999
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SHIP (INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
→
SHC (SHC1)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
-
NCI Pathway Database IL4-mediated signaling events:
SHC (SHC1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
Text-mined interactions from Literome
Wery-Zennaro et al., FEBS Lett 1999
:
In keratinocytes,
IL-4 induced JAK1 and JAK2 phosphorylation but, unlike in immune cells, IL-4 did not involve
JAK3 activation for its signaling
Haque et al., J Biol Chem 2000
:
We show that the SH2 domains of SOCS-2, SOCS-3, and cytokine-inducible SH2 containing protein are functionally redundant in regulating the
IL-4 dependent
Jak-Stat signaling ... Thus, the Thr-Phe motif in the Pre-SH2 domain plays a critical role in SOCS-3 mediated inhibition of the
IL-4 dependent
Jak-Stat signaling, likely by regulating the mode of SOCS-Jak interaction
Suzuki et al., Blood 2000
:
These results indicate that gamma(c)- and
Jak3 dependent signaling is
essential for
IL-4- and IL-9 induced proliferation and survival of murine mast cells, that the effects of IL-4 are mediated by type I IL-4R and that type II IL-4R is absent on mast cells, and that IL-4 phosphorylates the 65-kd isoform of Stat6 in mast cells in a gamma(c)- and Jak3 dependent manner
Doucet et al., Oncogene 2000
(Lung Neoplasms...) :
In addition to these pathways, in lung tumor myofibroblasts,
IL-4 and IL-13
induced the phosphorylation of
JAK3 and increased the phosphorylation of Tyk2
Day et al., Oncogene 2002
:
Our results suggest that the IL-4 and HGF pathways converge at multiple levels, and that
IL-4 dependent
Jak3 and STAT6 activities modulate signaling events independent of PI3K to enhance HGF dependent mitogenesis in myeloid cells, and possibly other common cellular targets
Doucet et al., Eur J Immunol 2002
(Inflammation) :
Here we show that in normal lung fibroblasts
IL-4 and IL-13
induce the expression of the gamma c chain and its association with
Janus kinase (JAK) 3 , while lung myofibroblasts constitutively express a gamma c chain displaying a limited association with JAK3
Lutz et al., J Immunol 2002
:
The
IL-4R signaling for DC maturation
requires the IL-4R alpha-chain and STAT6, but not
Janus kinase 3 , indicating that IL-4R type II signaling is preferentially responsible for these effects
Zhou et al., J Immunol 2003
:
Thus, in humans,
IL-4 alone is sufficient to drive AID expression, and CD40 signaling is required for optimal AID production ; IL-4 induced AID expression is mediated via the JAK/STAT signaling pathway, and can be negatively
regulated by the
JAK phosphatase activity of CD45
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Yamashita et al., FEBS Lett 2010
:
We found that flavones inhibited
IL-4 induced epsilon germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6,
janus kinase 3 , and IL-4Ralpha, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones
Horio et al., Naunyn Schmiedebergs Arch Pharmacol 2010
:
IL-4 activated STAT6 ( signal transducer and activator of transcription 6 ) in HeLa cells, and up-regulation of H1R mRNA and activation of STAT6 by
IL-4 were
inhibited by a specific
JAK3 ( Janus activated kinase 3 ) inhibitor
Heller et al., J Biol Chem 2012
:
Our data suggest that a smaller ( 5 amino acid ) interval than previously determined is necessary for
JAK3 activation/?C mediated signaling in
response to
IL-4 and IL-2
Keegan et al., Proc Natl Acad Sci U S A 1995
:
Interestingly, although
IL-4 induced the tyrosine phosphorylation of
JAK3 , we did not detect JAK3 phosphorylation in response to IL-13
Tortolani et al., J Immunol 1995
(Leukemia) :
In addition, IL-4 and IL-7 induced the rapid tyrosine phosphorylation of JAK3 and JAK1, and
IL-4 activated both
JAK3 and JAK1 phosphotransferase activity
Fenghao et al., J Clin Invest 1995
:
Congruous with the involvement of a Stat protein,
IL-4 induced robust
Janus kinase 3 (JAK3) activity in BL-2 cells ... These results show that IL-4 NAF is IL-4 Stat, which is activated by
JAK3 in
response to
IL-4 receptor engagement
Malabarba et al., J Biol Chem 1995
:
Indeed, when human IL4R alpha was stably expressed in mouse BA/F3 cells, robust
IL4 induced proliferation and
JAK3 activation occurred without detectable involvement of JAK1, JAK2, or TYK2
Brunn et al., J Biol Chem 1995
:
Both IL-2 and
IL-4 stimulated the rapid activation of JAK1 and
JAK3 , whereas JAK2 activity was unaffected by either cytokine
Welham et al., J Biol Chem 1995
(Leukemia, Erythroblastic, Acute...) :
IL-4 also
activated the
Jak-3-kinase , but, despite other similarities, IL-13 did not
Russell et al., Science 1994
(Severe Combined Immunodeficiency) :
IL-2,
IL-4 , IL-7 ( whose receptors are known to contain gamma c ), and IL-9 ( whose receptor is shown here to contain gamma c )
induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases Jak1 and
Jak3
Witthuhn et al., Nature 1994
:
Here we describe a new Jak family kinase, Jak-3, and demonstrate that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and
Jak-3 is activated in the
responses to interleukin-2 and
interleukin-4 in T cells and myeloid cells
Murata et al., J Immunol 1996
(Colonic Neoplasms) :
IL-4 also stimulated all three kinases and substrates, but unlike in immune cells, IL-4 did not
involve JAK3 activation for its signaling in colon cancer cell lines
Chuang et al., J Biochem 1996
(Carcinoma, Hepatocellular) :
Interleukin 4 , but not insulin,
stimulated the tyrosine phosphorylation of JAK1 and, to a lesser extent,
JAK2
Wang et al., J Immunol 1997
(Fibrosarcoma) :
It has been shown that
IL-4 induces the tyrosine phosphorylation of JAK1 and
JAK3 in the majority of hemopoietic cell types, and JAK2 and TYK2 in several other types
Taylor et al., J Biol Chem 1997
(Severe Combined Immunodeficiency) :
We found that although
IL-4 stimulation of X-SCID B cells did not
result in
Janus tyrosine kinase-3 (JAK3) phosphorylation, other IL-4 substrates including JAK1 and IRS-1 were phosphorylated
Chuang et al., Biochem Biophys Res Commun 1997
(Carcinoma, Hepatocellular) :
In contrast,
IL-4 stimulated tyrosine phosphorylation of JAK1,
JAK2 and tyk2 in this cell line
Candotti et al., Blood 1997
(Severe Combined Immunodeficiency) :
Abnormalities in tyrosine phosphorylation of
JAK3 in
response to interleukin-2 (IL-2) and
IL-4 were present in all patients
Siemasko et al., J Immunol 1998
:
The signal transduction pathway utilized by IL-4 to induce IgG1 involves tyrosine phosphorylation of the IL-4 receptor,
JAK1 , JAK3, and STAT6 proteins
induced by
IL-4 binding to the IL-4R
Harada et al., Biochem Biophys Res Commun 1998
:
Interleukin-4 (IL-4) has been shown to
activate Janus kinase (Jak)-1 and
Jak-3 , followed by activation of STAT ( signal transducers and activators of transcription ) 6
Matsumoto et al., J Immunol 1999
(Dermatitis, Atopic...) :
The stimulation with CD40L and/or
IL-4 resulted in tyrosine phosphorylation of
Janus kinase 3 (JAK3) in B cells, which was more strongly inducible in NC/Nga mice than in BALB/c mice