◀ Back to RAC1
JUN — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Scita et al., Nature 1999
:
The small guanine nucleotide ( GTP ) -binding protein
Rac regulates mitogen induced cytoskeletal changes and
c-Jun amino-terminal kinase (JNK) , and its activity is required for Ras mediated cell transformation
Kaminuma et al., Mol Cell Biol 2001
:
On the other hand, Vav induced the activation of
Rac1 or Cdc42 and c-Jun N-terminal kinase (JNK), enhanced the transcriptional and DNA binding activities of AP-1, and
induced increased phosphorylation of
c-Jun
Pervaiz et al., Oncogene 2001
(Carcinoma...) :
Rac is
involved in actin polymerization,
Jun kinase activation, and intracellular superoxide anion production, through distinct pathways in tumor cells
Habas et al., Genes Dev 2003
:
Wnt/Fz activation of
Rac is independent of Rho and
mediates Wnt/Fz activation of
Jun N-terminal kinase (JNK)
Honda et al., Genes Cells 2003
:
Cdc42, and presumably
Rac , activated in this way,
induced the activation of
c-Jun N-terminal kinase (JNK) , but not p38 mitogen activated protein ( MAP ) kinase or extracellular signal regulated kinase ( ERK )
Wroblewski et al., J Cell Sci 2003
(Neoplasm Invasiveness) :
RhoA acted through activation of both NF-kappaB and AP-1, whereas
Rac activated NF-kappaB but not
AP-1
Boureux et al., J Cell Sci 2005
:
Rac function
required both a
Jun N-terminal kinase (JNK) and a NADPH oxidase ( Nox ) pathway
Gerber et al., Cancer Res 2006
(Meningioma) :
Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating
Rac1 dependent
c-Jun-NH ( 2 ) -kinase signaling
Sakoda et al., J Dent Res 2006
:
Dominant negative
Rac1 severely
inhibited interleukin-1alpha induced NF-kappaB and
AP-1 promoter activity
Lee et al., Oncogene 2009
:
In summary, Galpha(12) and Galpha(13) regulate the expression of the TGFbeta1 gene through an increase in
Rho/Rac dependent
AP-1 activity, implying that the G-protein coupled receptor ( GPCR ) -Galpha(12) pathway is involved in the TGFbeta1 mediated transdifferentiation process
Nishita et al., Mol Cell Biol 2010
:
We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of
Rac1 inhibits Wnt5a induced
AP-1 activation
Venkatesan et al., J Mol Cell Cardiol 2010
:
EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via
Rac1 dependent PI3K/Akt/IKK/NF-kappaB
andMKK7/JNK/AP-1 signaling
Collins et al., J Biol Chem 1996
:
In 1321N1 cells, where thrombin stimulates G12 dependent mitogenesis, coexpression of
N17Rac1 or a dominant negative mutant of MEKK1 ( MEKKDelta ( K432M ) )
inhibits c-Jun/AP-1 sensitive reporter gene expression stimulated by thrombin or Galpha12
Westwick et al., Mol Cell Biol 1997
(Cell Transformation, Neoplastic) :
Rac1 is distinct from RhoA in its ability to bind and
activate the p65 PAK serine/threonine kinase, to induce lamellipodia and membrane ruffling, and to activate the
c-Jun NH2-terminal kinase (JNK)
Michiels et al., J Cell Biol 1997
:
Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for
Rac dependent membrane ruffling and
C-Jun NH2-terminal kinase activation
Li et al., J Biol Chem 1998
:
Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras,
Rac , and Cdc42 and
induces extracellular signal regulated and
c-Jun N-terminal kinase activation ... Ras controls the activation of extracellular signal regulated kinases ( ERKs ), while
Rac and Cdc42
regulate the
c-Jun N-terminal kinases (JNKs)
Malliri et al., J Cell Biol 1998
:
Our data establish a novel link between
AP-1 activity and EGFR
activation of
Rac and Rho, which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion