Gene interactions and pathways from curated databases and text-mining

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JUN — VIP

Text-mined interactions from Literome

Wang et al., J Neuroimmunol 2000 : The effects of VIP/PACAP on c-Jun and JunB expression lead to changes in the composition of the AP-l complexes, from c-Jun/Fos to JunB/Fos dimers, with a subsequent decrease in DNA binding and loss of transactivating activity
Foster et al., J Dent Res 2005 : In parallel, we showed that VIP inhibits nuclear translocation of NFkappaB and c-Jun in a time dependent manner, but does not decrease the expression of CD14 receptors
Son et al., Exp Neurol 2007 (Constriction, Pathologic...) : Moreover, transcription factor c-Jun regulates the expressions of both VIP and NPY in cultured DRG neurons ... To elucidate the role of c-Jun in the induction of neuropathic pain hypersensitivity, we examined whether activated c-Jun affects pain behavior and the expressions of VIP and NPY following chronic constriction injury ( CCI ) of rat sciatic nerve ... These results show that the activation of c-Jun in DRGs induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain following CCI
Mulderry et al., Eur J Neurosci 1996 : Regulation of VIP and other neuropeptides by c-Jun in sensory neurons : implications for the neuropeptide response to axotomy ... To determine whether VIP induction is dependent on transcriptional regulation by c-Jun , we exploited the fact that c-Jun and VIP are also induced in cultured sensory neurons ... VIP induction in sensory neurons therefore probably results from transcriptional activation by c-Jun acting in combination with other factor ( s ), possibly acting through the CRE