Gene interactions and pathways from curated databases and text-mining

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HDAC1 — KDM1A

Pathways - manually collected, often from reviews:

  • Reactome Reaction: HDAC1 → KDM1A (indirect_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kliebenstein et al., Mol Plant Microbe Interact 1999 : LSD1 regulates salicylic acid induction of copper zinc superoxide dismutase in Arabidopsis thaliana
Koipally et al., J Biol Chem 2000 : These data strongly suggest that CtBP contributes to a histone deacetylase activity independent mechanism of repression by Ikaros
Xiao et al., J Biol Chem 2000 : We further demonstrate that the N-terminal NRD interacts with the C-terminal region of NIK, thereby inhibiting the binding of NIK to its substrate IkappaB kinase ... Consistently, when expressed alone, the NRD potently inhibits NIK mediated NF-kappaB signaling
Brunori et al., J Virol 2001 (Neoplasms) : Tcf4 is constitutively activated by mutations in the adenomatous polyposis coli and beta-catenin genes in virtually all colon tumors and is constitutively repressed by Groucho and CtBP in normal tissue
Izutsu et al., Blood 2001 (Cell Transformation, Neoplastic...) : The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling
Vo et al., Mol Cell Biol 2001 : In this study, we show that the interaction between CtBP and the nuclear hormone receptor corepressor RIP140 is regulated similarly, in this case by p300/CBP itself
Izutsu et al., Oncogene 2002 (Leukemia, Myeloid) : Here, we demonstrate that AML1/Evi-1 interacts with CtBP in SKH1 cells, a leukemic cell line which endogenously overexpresses AML1/Evi-1 and that AML1/Evi-1 requires the interaction with CtBP to repress AML1 induced transactivation ... Here, we demonstrate that AML1/Evi-1 interacts with CtBP in SKH1 cells, a leukemic cell line which endogenously overexpresses AML1/Evi-1 and that AML1/Evi-1 requires the interaction with CtBP to repress AML1 induced transactivation
Atchison et al., EMBO J 2003 : Finally, we found that YY1 , as well as Polycomb, required the co-repressor protein CtBP for repression in vivo
Barnes et al., Nat Struct Biol 2003 : We describe here the binding, phosphorylation and functional regulation of CtBP by the p21 activated kinase 1 (Pak1) ... In the presence of NADH, Pak1 superphosphorylates CtBP and inhibits CtBP dehydrogenase activity, suggesting that preferential phosphorylation of active CtBP may alter secondary structures and influence both enzymatic and corepressor functions ... Pak1 regulation of CtBP represents a new model of corepressor regulation whereby cellular signaling cascades may influence gene expression in mammalian cells
Zhang et al., Cell 2003 : Expression of HIPK2 or exposure to UV irradiation reduced CtBP levels via a proteosome mediated pathway
Yadav et al., Environ Pollut 1987 : BHC stimulated TPO activity in this fish, during both in vitro and in vivo studies
Srinivasan et al., Genes Dev 2004 : These results reveal a new role for CtBP in controlling YY1 DNA binding and recruitment of PcG proteins to DNA
Alpatov et al., Mol Cell Biol 2004 : Nuclear speckle associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP mediated repression of the E-cadherin gene
Chan et al., Blood 2005 (Myelodysplastic Syndromes...) : These results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia ... These results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia
Zhang et al., Proc Natl Acad Sci U S A 2005 : Homeodomain interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis
Van Komen et al., J Cell Biol 2006 : Our results suggest that the NRD is required for efficient t-SNARE complex formation and does not recruit necessary scaffolding factors
Paliwal et al., Mol Cell Biol 2006 (Colonic Neoplasms) : Interaction with ARF resulted in proteasome dependent CtBP degradation ... Both ARF induced CtBP degradation and CtBP small interfering RNA led to p53 independent apoptosis in colon cancer cells ... ARF induction of apoptosis was dependent on its ability to interact with CtBP , and reversal of ARF induced CtBP depletion by CtBP overexpression abrogated ARF induced apoptosis
Sierra et al., Genes Dev 2006 : We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP mediated repression of Wnt target genes in normal, but not in colorectal cancer cells
Wang et al., J Biol Chem 2006 : Previously, we have identified the homeodomain interacting protein kinase 2 as such a regulator and demonstrated that HIPK2 activation causes Ser-422 phosphorylation and degradation of CtBP ... In this study, we found that c-Jun NH2-terminal kinase 1 activation triggered CtBP phosphorylation on Ser-422 and subsequent degradation, inducing p53 independent apoptosis in human lung cancer cells
Gopal et al., Cell cycle (Georgetown, Tex.) 2006 (Inflammation) : The resulting depletion of cellular HDAC1 levels lead to a consequent depletion of HDAC1 associated with the CDKN1A gene promoter and increased expression of its protein product, p21 ( WAF1/CIP1 )
Huang et al., Nature 2007 : p53 is regulated by the lysine demethylase LSD1
Arrese et al., Arch Biochem Biophys 2008 : Using lipoprotein complexes containing triolein it is shown that PKA mediated phosphorylation of Lsd1 promoted a 1.7-fold activation of the main fat body lipase demonstrating the direct link between Lsd1 phosphorylation and activation of lipolysis
Oikawa et al., J Biol Chem 2008 : As CtBP is reportedly involved in p53 independent programmed cell death , we examine here whether CIBZ is associated with apoptosis
Gocke et al., PloS one 2008 : ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers
Wang et al., Nat Genet 2009 : Our findings suggest that LSD1 demethylates and stabilizes Dnmt1 , thus providing a previously unknown mechanistic link between the histone and DNA methylation systems
Yang et al., J Mol Biol 2009 : Over-expression of CtBP potentiated the trans-repressive activity of HDGF ; on the other hand, knocking down CtBP attenuated the trans-repressive effect of HDGF ... Finally, fluorescent microscopy showed that HDGF induced the nuclear accumulation of CtBP , suggesting that HDGF forms a transcriptional complex with CtBP
Haga et al., EMBO J 2009 : Finally, CtBP1/BARS activated PLD1 in a synergistic manner with other PLD activators, including ADP-ribosylation factors as demonstrated by in vitro and intact cell systems
Kovi et al., Cell Death Differ 2010 : Expression profiling of BH3-only gene expression in ARF expressing or CtBP-deficient cells revealed that Bik was uniquely regulated by ARF/CtBP in colon cancer cells, whereas additional BH3-only proteins ( Bim, Bmf ) showed CtBP dependent repression in osteosarcoma cells
Neufeld et al., Adv Exp Med Biol 2009 (Colorectal Neoplasms) : This down-regulation of nuclear beta-catenin activity by APC most likely involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor CtBP
Lv et al., Eur J Cell Biol 2010 : LSD1 positively regulates the BUBR1 and MAD2 promoter activity and maintains local monomethylation status of H3K9, which is a repressive histone mark for gene transcription
Molvaersmyr et al., Nucleic Acids Res 2010 : Thus, c-Myb harbours two AFs, one that is constitutively active and one in the NRD being SUMO regulated ( SRAF )
Amente et al., Oncogene 2010 : In addition, we demonstrate that Myc binds and recruits LSD1 to the E-box chromatin and the formation of this complex is stimulated by cAMP-PKA
Skalska et al., PLoS Pathog 2010 (Epstein-Barr Virus Infections) : Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP ... These novel LCLs have revealed that the chromatin remodelling and epigenetic repression of p16(INK4A) requires the interaction of both EBNA3A and EBNA3C with CtBP
Lin et al., Oncogene 2010 : In the absence of LSD1 , Snai1 fails to repress E-cadherin
Madison et al., Oncogene 2010 : PARP inhibition attenuated activation of p21 transcription by both p53 independent and p53 dependent processes, in a CtBP dependent manner ... PARP inhibition attenuated activation of p21 transcription by both p53 independent and p53 dependent processes, in a CtBP dependent manner
Di et al., Nature structural & molecular biology 2010 : Loss of CtBP from the BRCA1 promoter through estrogen induction, depletion by RNA interference or increased NAD+/NADH ratio leads to HDAC1 dismissal, elevated histone acetylation and increased BRCA1 transcription
Urvalek et al., American journal of translational research 2011 : Interestingly, CtBP promoted sumoylation at K67 of wild-type but not AVALF mutant KLF8, and KLF8 interaction with CtBP was inhibited by treatment with the HDAC inhibitors, ectopic expression of the co-activators, or K93Q or K95Q mutation
Huang et al., Breast Cancer Res Treat 2012 (Breast Neoplasms) : We also demonstrated that inhibition of LSD1 activity by a pharmacological inhibitor, pargyline, or siRNA resulted in increased acetylation of H3K9 (AcH3K9)
Mulligan et al., Mol Cell 2011 : A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
Borrmann et al., Neurochem Int 2011 (Neuroblastoma) : Here, we show that p42 ( IP4 ) enhances the enzymatic activity of NRD 3-4 times
Le Douce et al., Nucleic Acids Res 2012 : In the present work, we report that the histone demethylase LSD1 represses HIV-1 transcription and viral expression in a synergistic manner with CTIP2
Rajabi et al., J Biol Chem 2012 (Breast Neoplasms) : MUC1-C blocks the interaction between TCF7L2 and the C-terminal binding protein (CtBP) , a suppressor of TCF7L2 mediated transcription
Cai et al., PloS one 2012 (Spinal Cord Injuries) : Taken together, it is suggested that : ( i ) in the presence of CtBP , CIBZ gene is involved in secondary injury process and trigger the activation of apoptotic caspase-3 and bax genes independent of p53 ; ( ii ) abrupt down-regulation of CtBP at 8 h is a sign of mitochondria dysfunction and the onset of cell death ; ( iii ) it could be used as an inhibitor or target drug of caspase-3 gene to improve spinal cord function
Yu et al., Biochem Biophys Res Commun 2012 (Breast Neoplasms) : The histone demethylase LSD1 is required for estrogen dependent S100A7 gene expression in human breast cancer cells ... Our data showed in vivo association of LSD1 with S100A7 promoters, confirming the potential role of LSD1 in regulating S100A7 expression ... Together, our data suggest that estrogen induced S100A7 expression mediated by the histone demethylase LSD1 may downregulate breast cancer cell proliferation, implying a potential tumor suppressor-like function for S100A7
Zhong et al., Invest Ophthalmol Vis Sci 2013 (Diabetes Mellitus, Experimental...) : Regulation of LSD1 by LSD1-siRNA ameliorated glucose induced decrease in H3K4 methylation at Sod2, and prevented decrease in Sod2 gene expression
Paliwal et al., Genes & cancer 2012 : We noted a strict positive correlation between CtBP2 and Tiam1 expression levels and that CtBP promotion of cell migration required CtBP dependent transcriptional activation of Tiam1 ... An analysis of the Tiam1 promoter revealed binding sites for the CtBP interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8 dependent CtBP transactivation of Tiam1
Vasilatos et al., Carcinogenesis 2013 (Breast Neoplasms) : Taken together, these results provide novel mechanistic insight into the breast cancer subtype dependent role of LSD1 in mediating HDAC activity and therapeutic efficacy of HDAC inhibitor
Kashyap et al., Mol Oncol 2013 : We show that functional depletion of LSD1 expression using siRNA in prostate cancer cells decreases VEGF-A and blocks androgen induced VEGF-A, PSA and Tmprss2 expression ... We show that functional depletion of LSD1 expression using siRNA in prostate cancer cells decreases VEGF-A and blocks androgen induced VEGF-A , PSA and Tmprss2 expression ... We show that functional depletion of LSD1 expression using siRNA in prostate cancer cells decreases VEGF-A and blocks androgen induced VEGF-A, PSA and Tmprss2 expression
Zhong et al., Diabetes 2013 (Diabetes Mellitus, Experimental...) : The role of LSD1 in MMP-9 activation was investigated in isolated retinal endothelial cells transfected with LSD1 small interfering RNA ( siRNA )
Ombra et al., Biochim Biophys Acta 2013 (Breast Neoplasms...) : Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA
Sonoda et al., Brain Res 1986 : The GSR was inhibited by electrical stimulation of the PAG/NRD
Sollerbrant et al., Nucleic Acids Res 1996 (Cell Transformation, Neoplastic) : This might suggest that CtBP binding can regulate E1A mediated transformation by modulating CR1 dependent control of transcription
Brown et al., J Interferon Cytokine Res 1997 : The NRD ( NF-kappa B/Rel/Dorsal ) complexes induced by LPS and IFN-gamma were further characterized by addition of antisera to electrophoretic mobility shift assay ( EMSA ) reaction mixtures ... The NRD ( NF-kappa B/Rel/Dorsal ) complexes induced by LPS and IFN-gamma were further characterized by addition of antisera to electrophoretic mobility shift assay ( EMSA ) reaction mixtures
Yu et al., J Biol Chem 1998 : This finding suggests that BRCA1 regulates gene expression, at least in part, by modulating CtBP mediated transcriptional repression
Kuhen et al., Virology 1999 : Deletion and substitution mutations indicated that the NRD negatively affected Pkr transcription by a mechanism dependent upon the KCS element