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LEF1 — SLC22A3

Text-mined interactions from Literome

Kim et al., Cell Biol Int 2002 : Here, we ask whether or not LEF-1 directly introduced into epithelial cells in an adenovirus construct can induce EMT ... Our experiments demonstrated, however, that overexpressed LEF-1 upregulates nuclear beta-catenin and promotes dramatic EMT in DLD-1 epithelial tumors that retain nuclear beta-catenin ... Thus, our results demonstrate that LEF-1 can induce EMT directly when its transcription activity is activated by stable nuclear beta-catenin
Medici et al., Mol Biol Cell 2006 : However, our results also demonstrate that a complete loss of E-cadherin and transformation to the mesenchymal phenotype are dependent on Smad signaling, which subsequently stimulates formation of beta-catenin/LEF-1 complexes that induce EMT
Medici et al., Mol Biol Cell 2008 : Finally, we determined that beta-catenin-LEF-1 complexes can promote EMT without upstream signaling pathways