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LIF — SMAD1
Text-mined interactions from Literome
Fukuda et al., Mol Cell Biol 2007
:
Here we found that
LIF induces expression of BMP2 via STAT3 activation and
leads to the consequent activation of
Smad1 to efficiently promote astrogliogenic differentiation of NECs ... The BMP antagonist Noggin abrogated
LIF induced
Smad1 activation and astrogliogenesis by inhibiting BMPs produced by NECs
PeƱuelas et al., Cancer Cell 2009
(Brain Neoplasms...) :
TGF-beta induces the self-renewal capacity of GICs, but not of normal human neuroprogenitors, through the
Smad dependent
induction of
LIF and the subsequent activation of the JAK-STAT pathway