Gene interactions and pathways from curated databases and text-mining

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LIF — SMAD1

Text-mined interactions from Literome

Fukuda et al., Mol Cell Biol 2007 : Here we found that LIF induces expression of BMP2 via STAT3 activation and leads to the consequent activation of Smad1 to efficiently promote astrogliogenic differentiation of NECs ... The BMP antagonist Noggin abrogated LIF induced Smad1 activation and astrogliogenesis by inhibiting BMPs produced by NECs
PeƱuelas et al., Cancer Cell 2009 (Brain Neoplasms...) : TGF-beta induces the self-renewal capacity of GICs, but not of normal human neuroprogenitors, through the Smad dependent induction of LIF and the subsequent activation of the JAK-STAT pathway