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LRP5 — TCF24

Text-mined interactions from Literome

Mi et al., J Cell Biochem 2005 : In the absence of exogenous Wnt 3a, full-length ( FL ) LRP6, but not LRP5 , increased TCF/LEF-1 transcriptional activity, however both significantly potentiated Wnt 3a-induced TCF/LEF-1 activation
Guo et al., Bone 2007 : Expression of LRP5DeltaN-V , which carries the allele p.1525V, induced higher beta-catenin/TCF-LEF activity compared to LRP5DeltaN-A, which carries the allele p.1525A
Bhat et al., Gene 2007 : In the presence of Wnt1, LRP5 or the HBM variant ( LRP5-G171V ) induces beta-catenin nuclear translocation and activates T cell factor ( TCF ) -luciferase reporter activity
Mi et al., J Neurochem 2007 : Interestingly, LRP6 which lacks its extracellular domain can constitutively activate TCF/LEF and potentiate the Wnt signal