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MAGEH1 — WNT16

Text-mined interactions from Literome

Gleason et al., Genes Dev 2002 : This indicates that pry-1, which encodes a C. elegans axin homolog, acts as a negative regulator of Wnt signaling in the VPCs. Loss of activity of the APC homolog apr-1 increases the penetrance of this Overinduced phenotype, suggesting that APR-1 may play a negative role in Wnt signaling in this process in C. elegans similar to APC proteins in other systems
Putzke et al., Proc Natl Acad Sci U S A 2010 : APR-1, the C. elegans APC ortholog, is similarly required to prevent HMP-2 relocalization and keeps it from participating in Wnt signal transduction ; this finding partially explains the paradoxical observation that APR-1 acts either negatively or positively in Wnt signaling, depending on context