Gene interactions and pathways from curated databases and text-mining

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MAML3 — NOTCH1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wu et al., Semin Cancer Biol 2004 (Cell Transformation, Neoplastic) : Here, we review our current understanding of the roles of the MAML proteins in Notch signaling, and their involvement in certain human cancers
Maillard et al., J Exp Med 2006 : These findings indicate that the Notch requirement during the beta-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional activation by Notch via the CSL/RBP-J-MAML complex
Köchert et al., Oncogene 2011 (Lymphoma) : Finally, in line with the essential role of MAML proteins for assembly and activity of the NOTCH transcriptional complex ( NTC ) , we show that MAML derived small-peptide constructs block NOTCH activity and disrupt NTC formation in vitro
Oyama et al., Development 2011 : Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo
Zhang et al., Development 2013 (Hyperplasia...) : Collectively, these findings indicated that Maml mediated Notch signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis and homeostasis through regulation of Klf4 and Klf5