Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jiang et al., J Mol Neurosci 2005 (MAP Kinase Signaling System) : A selective MAPK kinase inhibitor, U0126, blocked the H2O2 induced phosphorylation of Erk1/2 ( extracellular signal regulated kinase ) in PC12 cells and increased the levels of active caspase-3 in M-M17-26 under serum withdrawal or H2O2 treatment
Sawamura et al., J Neurochem 2003 (Niemann-Pick Diseases) : In CT43 cells, mitogen activated protein ( MAP ) kinase Erk1/2 was activated and the specific MAPK inhibitor, PD98059, attenuated the hyperphosphorylation of tau
Blaschke et al., Biochem Biophys Res Commun 2002 (Anoxia) : Hypoxia induced a time dependent activation of ERK 1/2 and p38 MAPK activation in human VSMCs, which were completely abolished by PD98059 or SB203580, respectively
Rose et al., J Immunol 1997 : The selective MAPK/extracellular signal regulated kinase-1 ( MEK-1 ) inhibitor PD 098059 inhibited activation of p42MAPK induced by Fc gamma R cross linking, but not p38 or JNK/SAPK activation
Sheng et al., J Neuroimmune Pharmacol 2009 (MAP Kinase Signaling System) : IL-1beta triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways, but WIN55,212-2 mainly inhibited p38 MAPK phosphorylation
Fujii et al., Biochem Biophys Res Commun 2004 (Carcinoma, Hepatocellular...) : CCL20 stimulated growth of HuH7 cells was abrogated by the inhibition of downstream signal transduction pathway mediated by p44/42 MAPK , but not by p38 MAPK or SAPK/JNK
Suzuki et al., Cytokine 2008 (Hemorrhage...) : Two hours thereafter, T cell production of IL-2 and IFN-gamma and activation of MAPK ( p38, ERK-1/2 and JNK ) were determined
Koch et al., Respir Med 2007 (Asthma) : In conclusion, ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma, and ( 2 ) ERK- and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on IFNgamma release is impaired in asthma
Pyne et al., Biochem J 1997 : This occurs via a pathway that involves : ( 1 ) the protein kinase C ( PKC ) -dependent activation of mitogen activated protein kinase ( MAPK); (2 ) the MAPK dependent phosphorylation and activation of cytosolic phospholipase A2 (cPLA2) and ( 3 ) the utilization of cPLA2 derived arachidonate by the cyclo-oxygenase pathway to produce prostaglandin E2 ( PGE2 )
Kumar et al., J Biol Chem 1998 : These results show that IL-1beta- or TNF induced LDL receptor expression requires ERK-1/2 activation, that the p38 ( MAPK ) pathway negatively regulates LDL receptor expression, and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells
Kozono et al., Biochem Biophys Res Commun 2010 : CP55940 ( CB1/CB2 agonist ) induced phosphorylation of the extracellular regulated kinases (ERK) 1/2 , p38 mitogen activated protein kinase ( p38MAPK ), and Akt in HGFs. Wound closure by CP55940 in an in-vitro scratch assay was significantly suppressed by inhibitors of MAP kinase kinase ( MEK ), p38MAPK , and phosphoinositol 3-kinase (PI3-K)
Jacquel et al., Oncogene 2006 (Leukemia) : Differentiation of K562 cells by the combination of PMA and SB required Erk1/2 activation, a threshold of JNK activation and p38 MAPK inhibition
Romano et al., Endocrinology 2006 : In the present study, we focused on the involvement of the phosphoinositide 3-kinase (PI3K)/Akt pathway in the MAPK ERK-1/2 regulation and PRL secretion in pituitary cells
McClelland et al., Proc Natl Acad Sci U S A 2010 (MAP Kinase Signaling System) : RNA interference and biochemical experiments support the model that ephrin-B3 regulates synapse density by directly binding to Erk1/2 to inhibit postsynaptic Ras/mitogen activated protein kinase signaling
Bocelli-Tyndall et al., Arthritis Rheum 2010 : Both MAPK/ERK-1/2 and phosphatidylinositol 3-kinase/Akt controlled cell proliferation and HLA-DR expression, but only MAPK/ERK-1/2 controlled the induction of the class II MHC transcription activator protein CIITA, the major determinant of HLA-DR transcription
Hasan et al., Circ Res 2008 : Inhibiting hemin induced ERK-1/2 activation by U0126 ( MAPK-inhibitor ), the antioxidant N-acetyl cysteine, the NADPH oxidase inhibitors apocynin and diphenyleneiodonium chloride, the superoxide scavenger tiron, or tricarbonyldichlororuthenium ( II ) -dimer ( carbon-monoxide donor ; CORM-2 ) blocked hemin induced Egr-1 expression
Raggatt et al., J Endocrinol 2000 : CT treatment of cells expressing the insert -ve, but not insert +ve hCTR, induced the phosphorylation of Erk1/2 MAPK , which persisted for at least 72 h. Treatment of cells expressing the insert -ve hCTR with the MAPK kinase ( MEK ) inhibitor, PD-98059, inhibited the phosphorylation of Erk1/2 and abrogated the growth inhibitory effects of salmon CT, the accumulation of cells in G2, and the associated induction of p21 ( WAF1/CIP1 )
Siddhanti et al., Endocrinology 1995 : We found that PMA stimulated DNA synthesis was associated with increments in tyrosine phosphorylation of p44mapk ( ERK1 ) and p42mapk ( ERK2 ) and activation of Raf-1, MKK, and MAPK in these cells ... FSK treatment of osteoblasts, which raised intracellular cAMP levels and inhibited DNA synthesis, blocked PKC stimulated tyrosine phosphorylation of p44mapk ( ERK1 ) and p42mapk ( ERK2 ) as well as inhibited PKC stimulated MAPK and Raf-1 activities
Khan et al., J Biol Chem 2000 : These data demonstrate that incubation of macrophages with alpha1 : SRARKQAASIKVAVSADR, but not intact laminin-1, triggers protein kinase C-dependent activation of MAPK ( erk1/2 ), leading to the up-regulation of proteinase expression
Mathur et al., Nat Med 2004 (MAP Kinase Signaling System) : ERK-1/2 inhibition or IL-10 neutralization restores CD40 induced p38MAPK activation and parasite killing in macrophages and the BALB/c mouse, a susceptible host
Chandra et al., Clin Exp Immunol 2008 (Leishmaniasis, Visceral...) : Parasites also modulated the TLR2 stimulated mitogen activated protein kinase ( MAPK ) pathway by suppressing MAPK P(38) phosphorylation and activating extracellular regulated kinase (ERK)1/2 phosphorylation
Rahman et al., J Immunol 2006 (Asthma...) : IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells : role of MAPK ( Erk1/2 , JNK, and p38 ) pathways
Jeong et al., J Pharm Pharmacol 2011 (MAP Kinase Signaling System) : Additionally, PD-98058 ( 10 µm ), a selective ERK 1/2 MAPK inhibitor, and SB-203580 ( 10 µm ), a selective p38 MAPK inhibitor , significantly reduced the MIGB induced contraction of ileal longitudinal muscles
Conejo et al., J Cell Physiol 2001 (MAP Kinase Signaling System) : This mitogenic effect of insulin was precluded by inhibition of p70S6-kinase ( either by rapamycin or by the PI3-kinase inhibitor LY294002 ) as well as by inhibition of p44/p42-MAPK with PD098059, but was not affected by inhibition of p38-MAPK
Suzuki et al., J Cell Physiol 2008 (Hemorrhage) : Two hrs thereafter, Kupffer cells and SMPhi production of IL-6, TNF-alpha, and IL-10, activation of MAPK ( p38, ERK-1/2 , and JNK ), and transcription factors ( NF-kappaB and AP-1 ) were determined
Matsubayashi et al., J Pathol 2008 (Breast Neoplasms...) : In addition, GRK4-over expressing cells activated the mitogen activated protein kinase ( MAPK ) mediated by ERK 1/2 and JNK phosphorylation in breast cancer derived cell lines