Gene interactions and pathways from curated databases and text-mining

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MAPK1 — SERPINE1

Text-mined interactions from Literome

Webb et al., J Cell Biol 2001 (Breast Neoplasms) : In MCF-7 cells, PAI-1 did not directly activate the mitogen activated protein ( MAP ) kinases , extracellular signal regulated kinase ( ERK ) 1 and ERK2, but instead altered the response to uPA so that ERK phosphorylation was sustained
Norata et al., Br J Haematol 2004 : Moreover, incubation with specific inhibitors of these kinases showed that p38MAPK was mainly involved in the Ox-HDL3 dependent PAI-1 induction
Klein et al., Cell cycle (Georgetown, Tex.) 2005 : Although some of these differences between Taxol and discodermolide were dose dependent, only discodermolide produced a doxorubicin-like induction of a senescence phenotype, including a senescence associated beta-galactosidase activity, up-regulation of PAI-1 and p66Shc, and a strong, sustained, Erk1/2 activation
Guo et al., Kidney Int 2005 (MAP Kinase Signaling System) : MAPK/AP-1 dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells
Mukai et al., Am J Physiol Heart Circ Physiol 2007 : The induction of PAI-1 by TNF-alpha and insulin is mediated , in part, by ERK and p38 MAPK
Yang et al., Exp Cell Res 2007 : Regulation of TGF-beta1/MAPK mediated PAI-1 gene expression by the actin cytoskeleton in human mesangial cells ... Our hypothesis is that the actin cytoskeleton is involved in TGF-beta1/MAPK mediated PAI-1 expression in human mesangial cells
Pasten et al., Thromb Res 2007 (MAP Kinase Signaling System) : An inhibitor of p38 MAPK had no effect on polyphenol induced repression of PAI-1
Bryan et al., Mol Cancer Res 2008 (Brain Neoplasms...) : Accordingly, the inhibition of mitogen activated protein kinase/extracellular signal regulated kinase kinase 1/2 and Rho-kinase, two downstream signaling cascades activated by S1P(2), blocked the activation of PAI-1 and uPAR mRNA expression by S1P
Nakajima et al., Neurosci Lett 2010 : In the present study, we investigated the relationship between MAPK activity and PAI-1 induction in PLGn stimulated astrocytes