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APP — MAPK3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rossner et al., Neurosci Lett 1999
:
Our data demonstrate, that activation of
mitogen activated protein ( MAP ) kinase alone is
sufficient to promote
APP secretion, whereas inhibition of MAP kinase will reduce APP secretion only when phospholipase Cgamma or phosphatidylinositol 3-kinase are additionally inhibited
Lee et al., Mol Med 2001
(Mammary Neoplasms, Experimental) :
Ad1-536 or AdL540Q infection inhibited T47D cell growth and induced apoptosis,
increasing Bax protein and phosphorylation of p38
mitogen-activated-protein kinase ( MAPK )
Ruiz-León et al., J Neurochem 2004
(Neuroblastoma) :
Taken together, our results suggest that simultaneous activation of at least two signalling pathways,
Ras/MAPK and PI3K/Akt, is
necessary to mediate a full activation of the
APP promoter by BDNF
Westra et al., Ann Rheum Dis 2006
(Carcinoma, Hepatocellular...) :
The
effects of p38
MAPK inhibition on
APP production and mRNA expression in four human hepatoma cell lines was investigated, after stimulation with interleukin (IL)6 and/or IL1beta or tumour necrosis factor alpha
Venezia et al., Ann N Y Acad Sci 2006
:
Finally, also in H4 cells the overexpression of
APP upregulates the levels of
phospho-ERK-1 and -2