Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Hui et al., Mol Cell Biol 2004 : PLD1 stimulated increases in MDM2 expression and suppression of p53 activation were blocked by inhibition of mTOR and the mitogen activated protein kinase pathway
Lyo et al., Biochem Biophys Res Commun 2010 (Kidney Neoplasms) : We report here that the PLD/mTOR dependent stabilization of HDM2 involves mTORC2 and the AGC family kinase serum- and glucocorticoid-inducible kinase 1 ( SGK1 )
Pääjärvi et al., FASEB J 2005 (Liver Neoplasms) : Taken together, these data indicate that statins induce an mTOR dependent Ser166 phosphorylation of Mdm2 , and this effect may attenuate the duration and intensity of the p53 response to DNA damage in hepatocytes