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MET — TCF3
Text-mined interactions from Literome
Boon et al., Cancer Res 2002
(Adenoma...) :
Moreover, in CRC cells, induction of dominant negative
TCF proteins and the consequent abrogation of beta-catenin/TCF mediated transcriptional activation
lead to a strong down-regulation of
Met expression
Cherukuri et al., Cancer Biol Ther 2005
(Colorectal Neoplasms) :
These results suggest that
Se-Met regulates COX-2 at transcriptional level by modulating the activity of NF-kappaB
transcription factor
Lim et al., Cancer Res 2008
(Bile Duct Neoplasms...) :
Accordingly, DHA treatment also decreased the beta-catenin mediated T cell factor/lymphoid enhancer factor (
TCF/LEF ) reporter activity, and
inhibited the expression of
c-Met , a beta-catenin controlled downstream gene implicated in cholangiocarcinogenesis
Mascarenhas et al., J Biol Chem 2009
(Adenocarcinoma...) :
These data support a model for a neoplastic pathway, where expression of a
transcription factor from development
activates the
MET receptor, a protein that has been directly linked to protumorigenic processes of resisting apoptosis, tumor growth, invasion, and metastasis