Gene interactions and pathways from curated databases and text-mining

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IL8 — MIF

Text-mined interactions from Literome

Murakami et al., Clin Exp Immunol 2002 (Colitis, Ulcerative...) : Study of intracellular cytokine expression showed that MIF induced significant levels of interleukin (IL)-1 and IL-8 in monocytes and DC from UC and CD patients
Ren et al., Int J Cancer 2003 (Carcinoma, Hepatocellular...) : MIF induced a significant dose dependent increase in IL-8 and VEGF production
Shimizu et al., Clin Exp Allergy 2004 (Eosinophilia) : The effects of cetirizine on MIF induced IL-8 production in A431 cells were examined by ELISA ... MIF stimulates IL-8 production in A431 cells ... Consistent with this, cetirizine significantly inhibited MIF induced IL-8 production
Li et al., Chin Med J (Engl) 2004 (Nasopharyngeal Neoplasms...) : This study aims to investigate macrophage migration inhibitory factor ( MIF ) -induced invasion of NPC cells in vitro and the effects on matrix metalloproteinases ( MMPs ) and interleukin-8 (IL-8) , and to study the mechanism of tumor cell invasion and metastasis in the early stage of NPC
Ren et al., Oncogene 2004 (Neuroblastoma) : In addition, we found that MIF induced a significant dose dependent increase of vascular endothelial growth factor and interleukin-8 secretion
Onodera et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : MIF induced IL-8 and IL-1beta transcriptional activation was studied in RA synovial fibroblasts by Northern blot analysis, enzyme linked immunosorbent assay, and electromobility shift assay ... The mRNA up-regulation of IL-8 and IL-1beta by MIF was inhibited by 2 tyrosine kinase inhibitors, a protein kinase C ( PKC ) inhibitor, an activator protein 1 (AP-1) inhibitor, and by an NF-kappaB inhibitor
Santos et al., J Rheumatol 2004 (Arthritis, Rheumatoid) : MIF significantly induced COX-2 and IL-6 protein and mRNA expression as well as PGE ( 2 ) and IL-8 production ... Neither antagonist inhibited MIF induced IL-8 ... MIF activates RA FLS COX-2 and IL-6 expression via p38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinase independent pathways
Ren et al., Ann Surg 2005 (Carcinoma, Squamous Cell...) : In addition, in vitro MIF stimulation of esophageal cancer cell lines induced a dose dependent increase in VEGF and IL-8 secretion
Roger et al., Eur J Immunol 2005 : Recombinant MIF counter regulated in a dose dependent fashion dexamethasone inhibition of TNF and IL-8 production by RAW 264.7 macrophages and U-937 promonocytes stimulated with lipopolysaccharides (LPS) or with LPS plus phorbol 12-myristate 13-acetate
Lebiedz et al., Helicobacter 2006 (Helicobacter Infections) : While interleukin-8 mRNA expression and interleukin-8 secretion were upregulated in gastric epithelial cells in vitro after H. pylori infection, no changes in MIF mRNA expression and MIF secretion could be detected
Xu et al., Cancer Lett 2008 (Breast Neoplasms...) : In addition, we investigated the expression of MIF in MDA-MB-231, MCF-7 ( breast cancer cell lines ) and MCF-10A ( epithelial cell line ) cells, and its effect on VEGF and IL-8 ... Exogenous MIF did not cause endothelial tube formation and migration but induced a dose dependent increase in VEGF and IL-8 secretion in breast cancer cell lines
Stojanović et al., Immunology 2009 (Inflammation) : Macrophage migration inhibitory factor stimulates interleukin-17 expression and production in lymph node cells
Kim et al., Korean J Intern Med 2010 (Arthritis, Rheumatoid) : MIF was also induced by interferon-?, CD40 ligand, interleukin-15 , interleukin-1ß, tumor necrosis factor-a, and transforming growth factor-ß
Reidy et al., J Biol Chem 2013 (Conjunctivitis, Bacterial...) : MIF promoted P. aeruginosa induced IL-8 responses via the formation of caveolin-1-rich `` signaling hubs '' in the corneal cells that led to elevated MAPK p42/p44 activation and sustained inflammatory signaling
Donnelly et al., Nat Med 1997 (Respiratory Distress Syndrome, Newborn) : We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion ( TNF alpha and IL-8 ), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration related fashion, the anti-inflammatory effects of glucocorticoids