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IL8 — MIF
Text-mined interactions from Literome
Murakami et al., Clin Exp Immunol 2002
(Colitis, Ulcerative...) :
Study of intracellular cytokine expression showed that
MIF induced significant levels of interleukin (IL)-1 and
IL-8 in monocytes and DC from UC and CD patients
Ren et al., Int J Cancer 2003
(Carcinoma, Hepatocellular...) :
MIF induced a significant dose dependent
increase in
IL-8 and VEGF production
Shimizu et al., Clin Exp Allergy 2004
(Eosinophilia) :
The effects of cetirizine on
MIF induced
IL-8 production in A431 cells were examined by ELISA ...
MIF stimulates
IL-8 production in A431 cells ... Consistent with this, cetirizine significantly inhibited
MIF induced
IL-8 production
Li et al., Chin Med J (Engl) 2004
(Nasopharyngeal Neoplasms...) :
This study aims to investigate
macrophage migration inhibitory factor ( MIF ) -induced invasion of NPC cells in vitro and the
effects on matrix metalloproteinases ( MMPs ) and
interleukin-8 (IL-8) , and to study the mechanism of tumor cell invasion and metastasis in the early stage of NPC
Ren et al., Oncogene 2004
(Neuroblastoma) :
In addition, we found that
MIF induced a significant dose dependent
increase of vascular endothelial growth factor and
interleukin-8 secretion
Onodera et al., Arthritis Rheum 2004
(Arthritis, Rheumatoid...) :
MIF induced
IL-8 and IL-1beta transcriptional activation was studied in RA synovial fibroblasts by Northern blot analysis, enzyme linked immunosorbent assay, and electromobility shift assay ... The mRNA
up-regulation of
IL-8 and IL-1beta by
MIF was inhibited by 2 tyrosine kinase inhibitors, a protein kinase C ( PKC ) inhibitor, an activator protein 1 (AP-1) inhibitor, and by an NF-kappaB inhibitor
Santos et al., J Rheumatol 2004
(Arthritis, Rheumatoid) :
MIF significantly
induced COX-2 and IL-6 protein and mRNA expression as well as PGE ( 2 ) and
IL-8 production ... Neither antagonist inhibited
MIF induced
IL-8 ...
MIF activates RA FLS COX-2 and IL-6 expression via p38 MAP kinase activation and
induces IL-8 via p38 and ERK MAP kinase independent pathways
Ren et al., Ann Surg 2005
(Carcinoma, Squamous Cell...) :
In addition, in vitro
MIF stimulation of esophageal cancer cell lines
induced a dose dependent increase in VEGF and
IL-8 secretion
Roger et al., Eur J Immunol 2005
:
Recombinant
MIF counter
regulated in a dose dependent fashion dexamethasone inhibition of TNF and
IL-8 production by RAW 264.7 macrophages and U-937 promonocytes stimulated with lipopolysaccharides (LPS) or with LPS plus phorbol 12-myristate 13-acetate
Lebiedz et al., Helicobacter 2006
(Helicobacter Infections) :
While
interleukin-8 mRNA expression and interleukin-8 secretion were upregulated in gastric epithelial cells in vitro after H. pylori infection, no changes in
MIF mRNA expression and MIF secretion could be
detected
Xu et al., Cancer Lett 2008
(Breast Neoplasms...) :
In addition, we investigated the expression of
MIF in MDA-MB-231, MCF-7 ( breast cancer cell lines ) and MCF-10A ( epithelial cell line ) cells, and its
effect on VEGF and
IL-8 ... Exogenous
MIF did not cause endothelial tube formation and migration but
induced a dose dependent increase in VEGF and
IL-8 secretion in breast cancer cell lines
Stojanović et al., Immunology 2009
(Inflammation) :
Macrophage migration inhibitory factor stimulates
interleukin-17 expression and production in lymph node cells
Kim et al., Korean J Intern Med 2010
(Arthritis, Rheumatoid) :
MIF was also
induced by interferon-?, CD40 ligand,
interleukin-15 , interleukin-1ß, tumor necrosis factor-a, and transforming growth factor-ß
Reidy et al., J Biol Chem 2013
(Conjunctivitis, Bacterial...) :
MIF promoted P. aeruginosa
induced IL-8 responses via the formation of caveolin-1-rich `` signaling hubs '' in the corneal cells that led to elevated MAPK p42/p44 activation and sustained inflammatory signaling
Donnelly et al., Nat Med 1997
(Respiratory Distress Syndrome, Newborn) :
We show in alveolar cells from patients with ARDS that
MIF augments pro-inflammatory cytokine secretion ( TNF alpha and IL-8 ), anti-MIF significantly
attenuates TNF alpha and
IL-8 secretion and MIF overrides, in a concentration related fashion, the anti-inflammatory effects of glucocorticoids