◀ Back to FGF2

FGF2 — MMP13

Text-mined interactions from Literome

Shimazu et al., J Periodontal Res 2003 : Furthermore, MMP-3 expression induced by bFGF was abrogated by U0126, a specific inhibitor of MEK1/2 and ERK1/2 in mitogen activated protein ( MAP ) kinase pathway, not by PD98059, a specific inhibitor of MEK1
Wang et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage ... To understand the molecular mechanisms that lead to increased MMP-13 expression and cartilage degeneration during the progression of osteoarthritis ( OA ), we have investigated the expression of the transcription factor RUNX2 in OA cartilage and the regulation of MMP-13 expression by RUNX2 and FGF2 in articular chondrocytes ... Inhibitors of MEK/ERK signaling blocked up-regulation of the MMP-13 promoter by RUNX2 and FGF2 , and also blocked the activation of RUNX2 by FGF2 ... FGF2 , which is present in OA synovial fluid, activated RUNX2 via the MEK/ERK pathway and increased MMP-13 expression
Im et al., J Biol Chem 2007 : Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes ... Also, our findings suggest that bFGF stimulation of MMP-13 required the activation of multiple MAPKs ( ERK, p38, and JNK ) by bFGF , and more importantly, bFGF activation of protein kinase C (PKC) delta played a key role in the MMP-13 stimulation ... Our results suggest that PKCdelta activation is a principal rate limiting event in the bFGF dependent stimulation of MMP-13 in human adult articular chondrocytes
Muddasani et al., J Biol Chem 2007 : We have previously found that the capacity for cartilage repair in human adult articular chondrocytes is severely compromised by minimal exposure to bFGF because bFGF reduces responsiveness to bone morphogenetic protein-7 and insulin-like growth factor-1 and induces MMP-13 through protein kinase Cdelta dependent activation of multiple mitogen activated protein kinase ( MAPK ) signaling pathways
Li et al., Arthritis Res Ther 2008 : Stimulation of bovine nucleus pulposus cells cultured in monolayer with FGF2 augmented the production of MMP-13 at the transcriptional and translational level in a dose dependent manner
Wang et al., Growth Factors 2009 : Results showed that FGF2 and IL-1beta both increased MMP-1 and -13 expression, while IL-1beta also increased MMP-3 mRNA levels
Giunciuglio et al., Int J Oncol 1995 : Also bFGF alone, a heparin dependent factor, alone can induce endothelial and smooth muscle cell invasion, MMP-2 production and PA activity
Yan et al., Arthritis Res Ther 2011 (Osteoarthritis) : Luciferase reporter gene assays were used to quantify the effects of FGF-2 and FGFR1 inhibitor on MMP-13 promoter activity
Yan et al., J Cell Biochem 2012 : Quantitative PCR analyses revealed that both Ras and PKCd contributed to FGF-2 mediated upregulation of MMP-13 , ADAMTS5, and repression of aggrecan gene
Sasaki et al., J Biochem 1998 : An MMP inhibitor partially suppressed the release of bFGF , indicating that matrix degradation is at least partially involved in the IL-1 stimulated bFGF release even if increased production of bFGF is related to the release
Uría et al., Am J Pathol 1998 (Chondroma...) : Collagenase-3 ( MMP-13 ) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor
Andersen et al., Anticancer Res 1998 (Bone Neoplasms...) : The CAPL protein expressed in cell-cultures appear to block the MMP induction by bFGF and Il-1 alpha