Gene interactions and pathways from curated databases and text-mining

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FGFR1 — MMP2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Rachagani et al., Carcinogenesis 2012 (Neoplasm Invasiveness...) : The downregulation of FGFR1 in turn led to downregulation of pAkt, pERK1/2, pNF-?B, pIkBa, uPA, MMP-9 , vimentin, N-cadherin, Twist, Slug and Zeb1 and upregulation of E-cadherin, Occludin, Cytokeratin-18 and Caspase-9 in MUC4 knockdown BXPC3 and Capan1 cells compared with scramble vector transfected cells
Levi et al., Proc Natl Acad Sci U S A 1996 : These studies demonstrate that FGFR1 may be a specific target for MMP2 on the cell surface, yielding a soluble FGF receptor that may modulate the mitogenic and angiogenic activities of FGF