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MMP28 — TGFB2
Text-mined interactions from Literome
Gallery et al., Microvasc Res 1999
(Pre-Eclampsia...) :
Neither tumor necrosis factor-alpha nor
transforming growth factor-beta , both thought to have significant roles in the control of placentation,
affected MMP secretion
Meisser et al., Mol Hum Reprod 1999
:
The aim of this study was to determine the
effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and
transforming growth factor beta ( TGFbeta ) on the secretion of
matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Nuttall et al., Endocrinology 2000
:
There was no effect of these growth factors on gelatinase or TIMP-1, -2, and -3, nor was there an
effect of
transforming growth factor-beta on any
MMP or TIMP examined
Parkin et al., Eur J Ophthalmol 2000
(Keratoconus) :
It is known that platelet derived growth factor ( PDGF ) and
transforming growth factor-beta ( TGF-beta ) are
involved in the regulation of
MMP activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues
Jenniskens et al., Osteoarthritis Cartilage 2006
:
TGFbeta2 and IGF1
had no effect on
MMP activity
Neumann et al., Invest Ophthalmol Vis Sci 2008
:
TGF-beta2 increased the expression of elastin ( 5X [ rtPCR ] /6X [ WB ] ), ColVIalpha2 ( 3X/5X ), ColVIalpha3 ( 7X/9X ),
MMP-2 ( 2X/2X ), TIMP-1/-3 ( 1.5X/2X ), and PAI-1 ( 8X/4X ) compared to untreated controls
Do et al., Mol Cancer Res 2008
(Neoplasm Metastasis...) :
When cancer cells were cultured on plastic, TGF-beta1,
TGF-beta2 , and TGF-beta3
induced pro-matrix metalloproteinase ( MMP ) secretion, loss of cell-cell junctions, down-regulation of E-cadherin, up-regulation of N-cadherin, and acquisition of a fibroblastoid phenotype, consistent with an epithelial-to-mesenchymal transition ... When cancer cells were cultured on a three-dimensional collagen matrix, TGF-beta1,
TGF-beta2 , and TGF-beta3
stimulated both
pro-MMP and active MMP secretion and invasion