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MMP9 — TGFB2

Text-mined interactions from Literome

Gallery et al., Microvasc Res 1999 (Pre-Eclampsia...) : Neither tumor necrosis factor-alpha nor transforming growth factor-beta , both thought to have significant roles in the control of placentation, affected MMP secretion
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Nuttall et al., Endocrinology 2000 : There was no effect of these growth factors on gelatinase or TIMP-1, -2, and -3, nor was there an effect of transforming growth factor-beta on any MMP or TIMP examined
Parkin et al., Eur J Ophthalmol 2000 (Keratoconus) : It is known that platelet derived growth factor ( PDGF ) and transforming growth factor-beta ( TGF-beta ) are involved in the regulation of MMP activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues
Han et al., J Biol Chem 2001 : In this report we demonstrate that tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta ( TGF-beta ) synergistically induce pro-MMP-9 in human skin as well as isolated dermal fibroblasts and epidermal keratinocytes
Wormstone et al., Invest Ophthalmol Vis Sci 2002 (Cataract) : TGF-beta2 also induced sustained release of MMP-2 and -9
Jenniskens et al., Osteoarthritis Cartilage 2006 : TGFbeta2 and IGF1 had no effect on MMP activity
Neumann et al., Invest Ophthalmol Vis Sci 2008 : TGF-beta2 increased the expression of elastin ( 5X [ rtPCR ] /6X [ WB ] ), ColVIalpha2 ( 3X/5X ), ColVIalpha3 ( 7X/9X ), MMP-2 ( 2X/2X ), TIMP-1/-3 ( 1.5X/2X ), and PAI-1 ( 8X/4X ) compared to untreated controls
Awasthi et al., Invest Ophthalmol Vis Sci 2008 (Cataract) : Medium from HLE B-3 cultures showed MMP-2 and -9 activities, which were induced by TGF-beta(2) treatment and inhibited by MG132 co-treatment
Do et al., Mol Cancer Res 2008 (Neoplasm Metastasis...) : When cancer cells were cultured on plastic, TGF-beta1, TGF-beta2 , and TGF-beta3 induced pro-matrix metalloproteinase ( MMP ) secretion, loss of cell-cell junctions, down-regulation of E-cadherin, up-regulation of N-cadherin, and acquisition of a fibroblastoid phenotype, consistent with an epithelial-to-mesenchymal transition ... When cancer cells were cultured on a three-dimensional collagen matrix, TGF-beta1, TGF-beta2 , and TGF-beta3 stimulated both pro-MMP and active MMP secretion and invasion
Konrad et al., Regul Pept 2009 (Prostatic Neoplasms) : Furthermore, a strong effect of TGF-beta 1 and TGF-beta 2 on the secretion of MMP-9 and PAI-1 was found
Shimizu et al., Cancer Res 1996 (Carcinoma...) : Secretion of gelatinase B by LuM1 cells was augmented by tumor necrosis factor alpha, transforming growth factor beta1 ( TGF-beta1 ), interleukin 1beta, or epidermal growth factor, and specific neutralizing antibodies abolished the induced increases
Esteve et al., Biochim Biophys Acta 1998 : We have also demonstrated that TGFbeta2 inhibited both IL-1- or TNFalpha induced gene expression and Gel B production in a dose dependent manner but had no effect on Gel A secretion ... The effect of TGFbeta2 on Gel B secretion was reversed by phorbol myristate acetate ( PMA ) ... Taken together, these data suggest that IL-1, TNFalpha and TGFbeta2 tightly regulate Gel B secretion in glioma cells, an enzyme which is believed to play an important role in the local invasion of brain tissue by tumor cells