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Wang et al., FASEB J 2005
(MPTP Poisoning) :
MPP+ induced COX-2 activation and subsequent dopaminergic neurodegeneration ... Using primary neuron-glia cultures, we aimed to determine 1 ) whether microglia participate in 1-methyl-4-phenylpryridinium (MPP) induced COX-2 activation and 2 ) whether the activation of COX-2 contributes to subsequent neurotoxicity ... Together, these results indicate that MPP induced COX-2 expression and subsequent PGE2 production depend on interactions between neurons and microglia
Hsieh et al., Naunyn Schmiedebergs Arch Pharmacol 2011
(Parkinson Disease) :
MPP ( + ) -induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress
Choi et al., J Ethnopharmacol 2012
(Edema...) :
Moreover, MPP inhibited COX-2 expression dose dependently