◀ Back to ROCK1
MYL6 — ROCK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Melendez-Vasquez et al., J Neurosci 2004
:
ROCK regulates
myosin light chain phosphorylation, which is robustly, but transiently, activated at the onset of myelination
Liu et al., J Biol Chem 2006
:
Dbs transformation is also associated with increased phosphorylation of
myosin light chain and stress fiber formation, both of which occur in a
ROCK dependent manner
Rösel et al., Mol Cancer Res 2008
(Neoplasm Invasiveness...) :
Using confocal and traction force microscopy, we showed that an up-regulation of
Rho/ROCK signaling
leads to increased cytoskeletal dynamics,
myosin light chain localization, and increased tractions at the leading edge of the cells and that all of these contributed to increased cell invasiveness in a three-dimensional collagen matrix
Kogata et al., Genes Dev 2009
:
In the absence of ILK, activated
Rho/ROCK signaling
induces the elevated phosphorylation of
myosin light chain leading to abnormally enhanced VSMC contraction in vitro and in vivo
Hassona et al., Am J Physiol Heart Circ Physiol 2010
(Disease Models, Animal...) :
The activation of
Rho/ROCK led to the inhibition of endothelial nitric oxide synthase expression ( 39 + or - 5.4 % ; P < 0.05 ) and phosphorylation ( 35 + or - 4.5 % ; P < 0.05 ) but also an increase in
myosin light chain 20 phosphorylation ( 372 %, P < 0.05 )
Komers et al., Br J Pharmacol 2011
(Diabetes Mellitus, Experimental) :
The effects of ROCK inhibitors in diabetic rats were modulated by prior protein kinase C ( PKC ) ß inhibition with ruboxistaurin, which abolished their effects on FF. Consistent with the renal vasodilator effects, the
ROCK inhibitors
reduced phosphorylation of
myosin light chain in diabetic kidneys
Pagiatakis et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
During contraction, VSMCs modulate calcium sensitivity through
RhoA/ROCK mediated inhibition of the
myosin light chain phosphatase complex ( MLCP )
Mirza et al., Cell Microbiol 2012
:
Modulation of enterocyte
myosin light chain phosphorylation, transepithelial fluorescein isothiocyanate-dextran fluxes, transepithelial resistance, cytoskeletal F-actin and tight junctional zonula occludens-1 ( ZO-1 ) by parasite cysteine proteases were measured in the
presence or absence of HMG-CoA reductase and
ROCK inhibition
Wilson et al., PloS one 2013
(Neoplasm Invasiveness) :
We further demonstrate that, in the absence of BCAR3, RhoA dependent signaling pathways appear to predominate, as evidenced by an increase in RhoA activity,
ROCK mediated phosphorylation of
myosin light chain II, and large ROCK/mDia1 dependent focal adhesions