Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Bornachea et al., Scientific reports 2012 (Carcinoma, Squamous Cell...) : The augmented expression of miR-21 , mediated by active mTOR and Stat3 signalling, conferred increased invasive properties to mouse keratinocytes in vitro and in vivo, whereas blockade of miR-21 in a metastatic spindle cell line inhibits metastasis development
Korkmaz et al., Autophagy 2012 (Starvation) : miR-376b controls starvation and mTOR inhibition related autophagy by targeting ATG4C and BECN1
Liu et al., J Cell Physiol 2012 : Our experimental data demonstrate that these effects occur not by direct binding to the MMP9 promoter, but by miR-520c and miR-373 directly targeting the 3'-untranslational region ( UTR ) of mRNAs of mTOR and SIRT1 ( negative regulators of expression of MMP9 via inactivating the Ras/Raf/MEK/Erk signaling pathway and transcription factor NF-?B activity ) ; and thus suppressing translation levels of SIRT1 and mTOR
Wu et al., Proc Natl Acad Sci U S A 2012 : However, excessive miR-17-92 expression enhances mammalian target of rapamycin (mTOR) signaling and strongly skews the differentiation toward short lived terminal effector cells
Sun et al., J Cell Biol 2010 : In this study, we report that expression of the muscle-specific micro-RNA ( miRNA ) miR-1 is regulated by mTOR both in differentiating myoblasts and in mouse regenerating skeletal muscle ... We have found that mTOR controls MyoD dependent transcription of miR-1 through its upstream enhancer, most likely by regulating MyoD protein stability
Iwaya et al., Carcinogenesis 2012 (Colorectal Neoplasms...) : The regulation of mTOR by miR-144 was examined with inhibitor miR-144 transfected cells
Jin et al., PloS one 2013 : We further demonstrated that miR-99 family members regulate cell proliferation, cell migration, and AKT/mTOR signaling ... Combined experimental and bioinformatics analyses revealed that miR-99 family members regulate AKT/mTOR signaling by targeting multiple genes, including known target genes ( e.g., IGF1R, mTOR ) and a new target ( AKT1 )
Nagaraja et al., Mol Endocrinol 2010 (Adenocarcinoma, Clear Cell...) : Overexpression of mir-100 inhibited mTOR signaling and enhanced sensitivity to the rapamycin analog RAD001 ( everolimus ), confirming the key relationship between mir-100 and the mTOR pathway
Sun et al., Med Oncol 2013 (Carcinoma, Squamous Cell...) : To investigate the molecular mechanism of miR-99a/100 induced apoptosis, luciferase reporter assays and Western blots were performed to demonstrate that the overexpression of miR-99a/100 suppressed the expression of mTOR by directly targeting its 3'UTR in a post-transcriptional manner