Gene interactions and pathways from curated databases and text-mining

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NEUROD1 — NEUROD2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Noma et al., Brain Res Mol Brain Res 1999 : NeuroD , a basic helix-loop-helix transcription factor, plays an important role in neuronal differentiation
Rodríguez-Rodríguez et al., J Neurochem 2004 : The transduction pathway by which oleic acid induces the expression of genes responsible for neuronal differentiation appears to be mediated by the transcription factor NeuroD2 , a regulator of terminal neuronal differentiation
Deisseroth et al., Neuron 2004 (Synaptic Transmission) : Excitation through this pathway acts to inhibit expression of the glial fate genes Hes1 and Id2 and increase expression of NeuroD , a positive regulator of neuronal differentiation
Park et al., J Cell Sci 2006 : In this study, we demonstrate that neurogenic basic helix-loop-helix ( bHLH ) factors Mash1, neurogenins ( Ngns ) and NeuroD play contrasting roles in Nurr1 induced DA neuronal differentiation
Boutin et al., Proc Natl Acad Sci U S A 2010 : NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis
Hu et al., Neural development 2011 : Our data indicate that Rbpj mediated canonical Notch signaling inhibits DRG neuronal differentiation , possibly by regulating NeuroD1 expression, and is required for DRG gliogenesis in vivo
Katakura et al., Stem cells international 2013 : In the present study, we examined the effect of eicosapentaenoic acid ( EPA ) and arachidonic acid ( AA ) on differentiation, expression of basic helix-loop-helix transcription factors ( Hes1, Hes6, and NeuroD ), and the cell cycle of cultured NSCs. EPA also increased mRNA levels of Hes1, an inhibitor of neuronal differentiation , Hes6, an inhibitor of Hes1, NeuroD , and Map2 mRNA and Tuj-1 positive cells ( a neuronal marker ), indicating that EPA induced neuronal differentiation
McCormick et al., Mol Cell Biol 1996 : Similar to neuroD, expression of neuroD2 in developing Xenopus laevis embryos results in ectopic neurogenesis, indicating that neuroD2 mediates neuronal differentiation
Olson et al., Mol Cell Neurosci 1998 (Choristoma...) : GSK3beta, which inhibits NeuroD function in vivo, blocks both Ngn1 induced and NeuroD induced neuronal differentiation , while Notch signaling inhibits only Ngn1 induced neuronal differentiation, confirming that NeuroD is downstream of Ngn1 and insensitive to Notch inhibition