Gene interactions and pathways from curated databases and text-mining

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IL10 — NOS1

Text-mined interactions from Literome

Heitmeier et al., J Biol Chem 1999 (Insulinoma) : Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1 induced inducible nitric-oxide synthase expression by islets of Langerhans
Miljkovic et al., Cell Mol Life Sci 2003 : The role of interleukin-17 in inducible nitric oxide synthase mediated nitric oxide production in endothelial cells
Kling et al., Int J Surg Investig 1999 (Disease Models, Animal...) : Interleukin-10 inhibits inducible nitric oxide synthase in an animal model of necrotizing enterocolitis
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells ... Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells ... Subsequent exposure to IL-10 results in an up-regulation of both endothelial nitric-oxide synthase ( NOS-3 ) expression and activity
Cunha et al., Biochem Biophys Res Commun 1992 : Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages ... Both the expression of NOS and the production of NO were inhibited by recombinant IL-10 in a dose dependent manner
Miljkovic et al., Cytokine Growth Factor Rev 2004 (Inflammation...) : Inducible nitric oxide synthase activation by interleukin-17
Ogando et al., Neuroimmunomodulation 2004 : In this study we have investigated the in vitro effect of IL-10 on NOS in the uterus ... IL-10 ( 50 and 100 ng/ml in vitro ) diminished NOS activity
Costa et al., Br J Pharmacol 2006 (Hyperalgesia...) : AM404 completely prevented the overproduction of NO and the overexpression of nNOS , inhibited the increase in tumour necrosis factor alpha (TNFalpha) and enhanced the production of interleukin-10
Ubol et al., J Infect Dis 2010 (Dengue) : Inhibition of IL-10 production by small interfering RNA down-regulated suppressor of cytokine signaling 3 gene expression, restored inducible nitric oxide synthase gene expression, and suppressed DENV replication
Ding et al., ACS Appl Mater Interfaces 2011 : The inhibition of inducible nitric oxide synthase and interleukin-1 expression and the activation of interleukin-10 were increased with increasing gelatin content
Thompson et al., J Neurotrauma 2013 (Spinal Cord Injuries) : The best characterized effects of IL-10 are anti-inflammatory-it downregulates pro-inflammatory species interleukin-1ß (IL-1ß), interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-a, interferon-?, matrix metalloproteinase-9, nitric oxide synthase , myeloperoxidase, and reactive oxygen species
Szabó et al., Eur J Pharmacol 1993 : We investigated the role of interleukin-1 in the induction of a Ca ( 2+ ) -independent nitric oxide ( NO ) synthase by bacterial endotoxin in vivo
Chesrown et al., Biochem Biophys Res Commun 1994 : Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages
Tetsuka et al., Proc Natl Acad Sci U S A 1994 : Cross-talk between cyclooxygenase and nitric oxide pathways : prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1
Bécherel et al., Eur J Immunol 1995 : Interleukin-10 inhibits IgE mediated nitric oxide synthase induction and cytokine synthesis in normal human keratinocytes
Kanno et al., Hypertension 1993 : Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells
Ianaro et al., Immunology 1994 (Drug Hypersensitivity...) : A nitric oxide synthase inhibitor reduces inflammation, down-regulates inflammatory cytokines and enhances interleukin-10 production in carrageenin induced oedema in mice
Loftis et al., J Infect Dis 1997 : Differential effects of pentoxifylline and interleukin-10 on production of tumor necrosis factor and inducible nitric oxide synthase by murine macrophages
Ribbons et al., Eur J Pharmacol 1997 (Colitis) : In addition, the 10-fold elevation in nitric oxide release, 5-fold rise in colonic nitrite production and enhanced expression of inducible nitric oxide synthase , associated with TNBS colitis, was not suppressed by interleukin-10
Heitmeier et al., J Biol Chem 1997 : Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1
Hauber et al., Cell Immunol 1997 : We show that gene expression of IL-1 alpha, IL-1 beta, IL-6, granulocyte-colony stimulating factor, and IL-10 was induced in both cell fractions, whereas increased mRNA levels of interferon-gamma and the inducible nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs