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IL10 — NOS1
Text-mined interactions from Literome
Heitmeier et al., J Biol Chem 1999
(Insulinoma) :
Prolonged STAT1 activation is associated with interferon-gamma priming for
interleukin-1 induced inducible
nitric-oxide synthase expression by islets of Langerhans
Miljkovic et al., Cell Mol Life Sci 2003
:
The
role of
interleukin-17 in inducible
nitric oxide synthase mediated nitric oxide production in endothelial cells
Kling et al., Int J Surg Investig 1999
(Disease Models, Animal...) :
Interleukin-10 inhibits inducible
nitric oxide synthase in an animal model of necrotizing enterocolitis
Cattaruzza et al., J Biol Chem 2003
:
Interleukin-10 induction of
nitric-oxide synthase expression
attenuates CD40 mediated
interleukin-12 synthesis in human endothelial cells ...
Interleukin-10 induction of
nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells ... Subsequent exposure to
IL-10 results in an up-regulation of both endothelial
nitric-oxide synthase ( NOS-3 ) expression and activity
Cunha et al., Biochem Biophys Res Commun 1992
:
Interleukin-10 (IL-10) inhibits the induction of
nitric oxide synthase by interferon-gamma in murine macrophages ... Both the expression of
NOS and the production of NO were
inhibited by recombinant
IL-10 in a dose dependent manner
Miljkovic et al., Cytokine Growth Factor Rev 2004
(Inflammation...) :
Inducible
nitric oxide synthase activation by
interleukin-17
Ogando et al., Neuroimmunomodulation 2004
:
In this study we have investigated the in vitro
effect of
IL-10 on
NOS in the uterus ...
IL-10 ( 50 and 100 ng/ml in vitro )
diminished NOS activity
Costa et al., Br J Pharmacol 2006
(Hyperalgesia...) :
AM404 completely prevented the overproduction of NO and the overexpression of
nNOS , inhibited the increase in tumour necrosis factor alpha (TNFalpha) and
enhanced the production of
interleukin-10
Ubol et al., J Infect Dis 2010
(Dengue) :
Inhibition of
IL-10 production by small interfering RNA down-regulated suppressor of cytokine signaling 3 gene expression,
restored inducible
nitric oxide synthase gene expression, and suppressed DENV replication
Ding et al., ACS Appl Mater Interfaces 2011
:
The inhibition of inducible
nitric oxide synthase and interleukin-1 expression and the
activation of
interleukin-10 were increased with increasing gelatin content
Thompson et al., J Neurotrauma 2013
(Spinal Cord Injuries) :
The best characterized
effects of
IL-10 are anti-inflammatory-it downregulates pro-inflammatory species interleukin-1ß (IL-1ß), interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-a, interferon-?, matrix metalloproteinase-9,
nitric oxide synthase , myeloperoxidase, and reactive oxygen species
Szabó et al., Eur J Pharmacol 1993
:
We investigated the
role of
interleukin-1 in the induction of a Ca ( 2+ ) -independent
nitric oxide ( NO ) synthase by bacterial endotoxin in vivo
Chesrown et al., Biochem Biophys Res Commun 1994
:
Regulation of inducible
nitric oxide synthase mRNA levels by LPS, INF-gamma, TGF-beta, and
IL-10 in murine macrophage cell lines and rat peritoneal macrophages
Tetsuka et al., Proc Natl Acad Sci U S A 1994
:
Cross-talk between cyclooxygenase and nitric oxide pathways : prostaglandin E2 negatively modulates
induction of
nitric oxide synthase by
interleukin 1
Bécherel et al., Eur J Immunol 1995
:
Interleukin-10 inhibits IgE mediated
nitric oxide synthase induction and cytokine synthesis in normal human keratinocytes
Kanno et al., Hypertension 1993
:
Induction of
nitric oxide synthase gene by
interleukin in vascular smooth muscle cells
Ianaro et al., Immunology 1994
(Drug Hypersensitivity...) :
A
nitric oxide synthase inhibitor reduces inflammation, down-regulates inflammatory cytokines and
enhances interleukin-10 production in carrageenin induced oedema in mice
Loftis et al., J Infect Dis 1997
:
Differential
effects of pentoxifylline and
interleukin-10 on production of tumor necrosis factor and inducible
nitric oxide synthase by murine macrophages
Ribbons et al., Eur J Pharmacol 1997
(Colitis) :
In addition, the 10-fold elevation in nitric oxide release, 5-fold rise in colonic nitrite production and enhanced expression of inducible
nitric oxide synthase , associated with TNBS colitis, was not
suppressed by
interleukin-10
Heitmeier et al., J Biol Chem 1997
:
Interferon-gamma increases the sensitivity of islets of Langerhans for inducible
nitric-oxide synthase expression
induced by
interleukin 1
Hauber et al., Cell Immunol 1997
:
We show that gene expression of IL-1 alpha, IL-1 beta, IL-6, granulocyte-colony stimulating factor, and
IL-10 was
induced in both cell fractions, whereas increased mRNA levels of interferon-gamma and the inducible
nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs